Abstract: Objective To investigate the comorbidities of metabolic diseases and chronic nephropathy in physical examination population in Tianchang region and analyze the related factors, to provide the basis for disease prevention and control in this region. Methods A convenient sampling method was adopted to include the people who underwent physical examination in Tianchang People's Hospital, Tianchang Hospital of Traditional Chinese Medicine, and Tianchang Tiankang Hospital from January to December 2022 for this investigation. The physical examination data and the information of life behaviors and habits of the physical examinees were collected by questionnaires. The types of metabolic diseases and chronic nephropathy comorbidities were analyzed by descriptive method. Multivariate logistic regression was used to analyze the influencing factors of metabolic disease and chronic nephropathy comorbidity. Results A total of 5 512 individuals were included in the health examination, including 3 788 patients with metabolic diseases, accounting for 68.72%; 662 patients with chronic nephropathy, accounting for 12.01%. There were 531 patients with metabolic diseases combined with chronic nephropathy, accounting for 9.63% (531/5 512). Multivariate logistic regression analysis showed that age (OR=1.480 for 45-<60 years old, OR=1.223 for ≥ 60 years old), BMI (OR=1.065 for 24.0-<30.0 kg/m², OR=2.275 for ≥ 30.0 kg/m²), smoking (OR=1.164), drinking (OR=1.126), place of residence (OR=1.365 for urban areas), sleep status (OR=1.292 for insufficient sleep), daily working hours (OR=1.201 for >8 hours), weekly exercise (OR=1.553 for 0-1 time), history of gastrointestinal diseases (OR=1.306), weekly fruit intake (OR=1.130 for 0-1 time), frequent consumption of hot pot (OR=1.192), and frequent consumption of late night snacks (OR=1.290) were independent influencing factors of comorbidity of metabolic diseases and chronic nephropathy (all P<0.05). Conclusions The incidence of comorbidity of metabolic diseases and chronic nephropathy in this region is relatively high, among which overweight and obesity, hypertension, and diabetes are the main types of comorbidity of metabolic diseases with chronic nephropathy. In clinical practice, more efforts should be made to promote diet guidance and exercise guidance to reduce the incidence.

Key words: Physical examination population, Metabolic disease, Chronic nephropathy, Disease status, Influencing factor