Abstract: Objective To assess the economic burden of influenza among preschool children in Yuexiu District of Guangzhou, and to carry out health economic evaluation on influenza vaccine, so as to provide a basis for the development of immunization planning strategies. Methods Taking the sick children of 9 influenza like outbreaks in childcare settings of Yuexiu District, Guangzhou from January to June 2019 as the research object, the economic burden was assessed by questionnaire survey. Based on an outbreak, SEIAR dynamical model was established to simulate the epidemic trend under different vaccination strategies and evaluate its economic effect. Results The total economic burden of the sick children per capita was 1293.56 yuan （95% UI : 1 096.23-1 592.84）, including 422.56 （95% UI: 320.71-555.29） yuan for direct medical expenses per capita, 125.95 yuan （95% UI: 82.41-188.80） for direct non-medical expenses per capita and 797.03 yuan （95% UI: 661.50-938.76） for indirect economic losses per capita. According to the evaluation, one dose of trivalent influenza vaccine before the epidemic season could reduce one influenza case with an investment of 226.19 yuan, and a profit of 5.72 yuan could be obtained with an investment of 1 yuan; Two doses of trivalent influenza vaccine could reduce one influenza case with an investment of 178.77 yuan, and a profit of 7.24 yuan could be obtained with an investment of 1 yuan; One case of influenza could be reduced by 315.83 yuan for the vaccination of tetravalent influenza vaccine, and a profit of 4.10 yuan could be obtained with an investment of 1 yuan. Conclusion The economic burden of influenza like outbreaks in childcare settings in Yuexiu District of Guangzhou is relatively high, but two doses of trivalent influenza vaccine before the epidemic season can achieve positive benefits and the best cost-benefit ratio.

Key words: Influenza virus, Economic burden, Dynamical model, Influenza vaccine, Cost, Benefit