Abstract: Objective To analyze the direct economic burden and influencing factors of stroke patients in Xi'an. Methods The data of stroke patients were collected from two tertiary hospitals and two secondary hospitals' medical record management information systems and fee collection systems monitored in the Xi'an Cardiovascular Disease Monitoring System from October 2019 to June 2022. Descriptive analysis method was used to analyze the direct economic burden of stroke patients, and univariate and multivariate analysis methods were used to analyze the relevant factors affecting direct economic burden. Results The median direct economic burden of stroke patients in outpatient clinics was 983.27 yuan, with the highest proportion being examination expenses （58.32%） and drug expenses （19.34%）. The median direct economic burden of hospitalized stroke patients was 14 660.71 yuan, with the highest proportion being hospitalization drug expenses （58.19%） and examination expenses （14.60%）. Multiple linear regression analysis showed that per capita monthly income of households （β'=0.104）,whether or not first visit （β'=0.354）, diabetes （β'=0.214）, hypertension （β'=0.368）, and type of medical insurance （β'=0.351） were factors influencing the direct economic burden of outpatients with stroke. Age （β'=0.265）, per capita monthly income of households （β'=0.125）,stroke type （β'=0.369,0.214）, whether or not first visit （β'=0.547）, diabetes （β'=0.621）, hypertension （β'=0.425）, length of hospital stays （β'=0.658）, discharge （β'=0.687）, emergency admission （β'=0.854）, surgery （β'=0.852）, and type of medical insurance （β'=0.862, 0.241） were factors influencing the direct economic burden of hospitalized stroke patients. Conclusions The largest direct economic burden of stroke patients is medical expense. The direct economic burden of outpatient and hospitalized stroke patients can be reduced by early prevention, intervention, and treatment to reduce the admission rate, or by optimizing the treatment procedures and improving the level of treatment to shorten the hospitalization time, thus enabling the effective use of health resources.

Key words: Stroke, Direct economic burden, Medical expense, Influencing factor