Abstract: Objective To understand the comorbidity of young and middle-aged non-dialyzed patients with chronic kidney disease （CKD） and its influencing factors, so as to provide basis for the prevention and control of CKD comorbidity. Methods Young and middle-aged non-dialyzed patients with CKD hospitalized in a hospital from January to August 2020 were selected to evaluate the comorbidity status by using the self-designed general information questionnaire and the cumulative illness rating scale （CIRS）. Results A total of 987 patients were finally included, mainly male （59.8%） and 18-44 years old （53.2%）. The prevalence of comorbidity in young and middle-aged non-dialyzed patients with CKD was 85.3%. Hypertension （13.5%）, diabetes mellitus （6.4%）, liver disease （6.8%） and pulmonary infection （4.6%） were the most common comorbidities. Hypertension and diabetes mellitus were the most common comorbidities in the two chronic disease modes （6.3%）. The score of CIRS was 7 （5, 9）, and 882 cases （89.4%） were in mild comorbidity. Gender （β'=-0.067）, age （β'=0.061） and number of comorbidities （β'=0.622） were the influencing factors of CIRS score （P< 0.05 or P<0.01）. Conclusion The comorbidity of young and middle-aged non-dialyzed patients with CKD can't be ignored. The health administrative department should improve the management awareness of chronic diseases and take corresponding measures to improve the health level of young and middle-aged patients.

Key words: Young and middle-aged, Chronic kidney disease, Comorbidity, Hypertension, Diabetes mellitus