Abstract: Objective To explore the effects of different management modes on self‐management ability and blood glucose control in patients with type 2 diabetes mellitus （T2DM）. Methods Patients with T2DM diagnosed in a tertiary hospital in Suzhou from October 2019 to August 2022 were selected and divided into standard group and intensive group according to the random number table method, and then further divided into simple intensive group and comprehensive group according to the willingness of the intensive group. According to the health management service specification for T2DM patients, the standardized management, intensive management, and comprehensive management of diabetes were designed. The Chinese version of the Summary of Diabetes Self‐Care Activities （SDSCA） and the Diabetes Specific Quality of Life （DSQL） were used to evaluate the self‐management ability and quality of life of patients before and 6 months after management, and blood glucose control was compared. Results A total of 1 598 T2DM patients were included, including 752 patients in the standard group, 524 patients in the simple intensive group, and 322 patients in the comprehensive group. After 6 months of management, fasting blood glucose （FBG） and 2-hour postprandial plasma glucose （2hPG） levels in 3 groups were decreased, and FBG and 2hPG levels in comprehensive group were lower than those in simple intensive group and standard group （all P<0.01）. The compliance rate of blood glucose control in standard group was 29.92% （225/752）, simple intensive group was 30.15% （158/524）, and comprehensive group was 30.75% （99/322）, there was no statistically significant difference （χ²=0.073, P>0.05）. The scores of all dimensions and total score of SDSCA in three groups were increased, while the scores of all dimensions and total score of DSQL were decreased, and the scores of the comprehensive group were better than those of the simple intensive group and the standard group （all P<0.01）. Conclusion The comprehensive management of T2DM patients is more conducive to improving their self‐management ability and has a positive impact on blood glucose compliance, thereby improving their quality of life.

Key words: Type 2 diabetes mellitus, Self‐management ability, Blood glucose, Quality of life, Management mode