Abstract: Objective To understand epidemic intensity and trend of hand, foot, and mouth disease (HFMD) in Liping County so as to provide the basis for developing control strategies. Methods Descriptive epidemiological method was used to analyze outbreaks of HFMD in Liping County from 2009 to 2012. Results A total of 504 cases of HFMD were reported and the average annual incidence rate was 23.91/100 000. Of all reported cases, 7 were severe cases (rate of severe cases, 1.39%) and 3 deaths (mortality rate, 0.14/100 000); 368 were male and 136 were female, with a sex ratio of 2.7∶1; 426 (84.52%) cases aged at 1-3 years; 460 (91.27%) were scattered children. Clear seasonality of HFMD occurrence was observed. Epidemic peaks were in April-June (180 cases, 35.71%) and November-December (137, 27.18%). Conclusion Incidence of HFMD was relatively low in Liping County during 2009-2012 and mainly occurred in scattered children aged 1-3 years. HFMD prevention and control should be strengthened for the scattered children.