Abstract: Objective To investigate the hand, foot, and mouth disease (HFMD) epidemic characteristics in Buji Street, Longgang District so as to provide the basis for HFMD prevention and control.Methods Data of HFMD of Buji street from 2010 to 2012 were collected through the National Disease Surveillance Information Reporting System and epidemiological analysis was conducted. Results A total of 9 112 HFMD cases were reported from 2010 to 2012, including 6 severe cases and 1 death. The average annual incidence rate was 314.1/100 000. Of all cases, 5 711 were male and 3 401 were female, with a sex ratio of 1.68∶1; 8 627 cases (94.68%) were children aged 5 years or below; 8 737 cases (95.88%) were scattered and kindergarten children. Epidemic peak was from May to September, when 6 011 cases (65.97%) were reported. Of 53 samples collected, 17 were positive for enteric virus (positive rate, 32.08%), including 10 strains of EV 71 and 6 of CV A16. Conclusion Obvious seasonality and differences in age and gender were observed in HMFD cases of Buji Street, Longgang District, Shenzhen City. HFMD surveillance should be strengthened and more attention should be paid to the prevention and control for scattered and kindergarten children.