Abstract: ObjectiveTo understand the proportion, epidemic characteristics and influencing factors of late diagnosed HIV/AIDS among the new cases reported between 2010 and 2016 in Guangdong Province. MethodsThe data of the newly reported HIV/AIDS cases from 2010 through 2016 in Guangdong were collected from the National AIDS Prevention and Information System. Descriptive analysis was conducted on the late diagnosed HIV/AIDS cases, and multivariate logistic regression was performed to analyze the related influencing factors. ResultsA toal of 47 343 HIV/AIDS cases were reported in Guangdong Province from 2010 to 2016, including 19 624 late diagnosed cases (41.5% of the total cases). The proportion of late diagnosed cases decreased in the past 7 years (P< 0.01). Multivariate logistic regression analysis showed that female patients had lower risk of late diagnosed than male ones（OR=0.820）; the risk of late diagnosed cases in group aged over 20 years was higher than that in group <20 years （OR=1.720 - 5.265）; compared with unmarried patients, the married（OR=1.255）, divorced or widowed（OR=1.199）had higher risk of late diagnoses; those with college degree or above had lower risk of late diagnoses than illiterates（OR=0.823）. Compared with the cases derived from special investigation, cases from medical institutions（OR=3.110）, VCT（OR=1.687）and STD clinics（OR=1.569）tended to have a greater risk; and the cases who had blood transfusion experience had higher risk of late diagnoses compared with the cases who had experienced heterosex（OR=0.580）, homosex （OR=0.404）or drug injection（OR=0.588）. ConclusionThe proportion of late diagnosed cases showed a downtrend among the newly reported HIV/AIDS cases in Guangdong Province from 2010 to 2016. Gender, age, marital status, educational level, discovery approach and route of infection were influencing factors for late diagnoses.