关键词: 血小板, 谷氨酰胺转移酶, 干扰素γ诱导蛋白-10, 慢性乙型肝炎

Abstract: Objective To investigate the correlation and prevention significance of platelet （PLT）, glutaminyltransferase （GGT）, and interferon γ-inducible protein-10 （IP-10） levels with disease progression in patients with chronic hepatitis B virus infection. Methods Patients with chronic hepatitis B diagnosed and treated in a hospital in Shangqiu City from September 2019 to August 2021 were selected as the research subjects. According to different stages of disease progression, set up a simple chronic hepatitis B group （hepatitis group）, chronic hepatitis B post-cirrhosis group （liver cirrhosis group）, and chronic hepatitis B-related primary liver cancer group （liver cancer group）, and set up healthy people as the control group. Data collection and physical examination were performed on the research subjects. At the same time, fasting venous blood was collected for albumin （ALB）, globulin （GLB）, aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, PLT, GGT, IP-10, and other indicators detection. Pearson analysis method was used to analyze the correlation between PLT, GGT, IP-10, and liver function indicators, and the receiver operating characteristic curve （ROC） and area under ROC （AUC） were used to analyze the value of PLT, GGT, and IP-10 evaluating the liver cirrhosis and liver cancer. Results A total of 524 chronic hepatitis B patients with different disease progression stages were included, including 152 in the hepatitis group, 141 in the liver cirrhosis group, 131 in the liver cancer group, and 140 healthy people （control group）. There was no significant difference in age, gender, drinking history, smoking history, and past disease history among the four groups （all P>0.05）, but there was a significant difference in BMI distribution （P<0.01）. The test results and abnormal rate of AST, ALT, GGT, IP-10, ALB, GLB, and PLT between the four groups were statistically significant （all P<0.01）. PLT was negatively correlated with AST and ALT, and positively correlated with ALB and GLB （P<0.01）; GGT and IP-10 were positively correlated with AST and ALT, and negatively correlated with ALB and GLB （P<0.01）. The results of the ROC curve showed that the AUC of liver cirrhosis assessed by PLT and GGT combined with IP-10 was 0.894, which was more significant than PLT （0.828）, GGT （0.798）, and IP-10 （0.717）, and the AUC of liver cancer assessed by PLT and GGT combined with IP-10 was 0.945, which was more significant than PLT （0.854）, GGT （0.825）, and IP-10 （0.889）. Conclusion PLT, GGT, and IP-10 are dynamic changes in the process of chronic hepatitis B, liver cirrhosis, and liver cancer, which are closely related to the progress of chronic hepatitis B patients. They can be used as predictive markers of liver cirrhosis and liver cancer and provide a reference for monitoring and preventing chronic hepatitis B disease progression.

Key words: Platelet, Glutaminyltransferase, Interferon γ-inducible protein-10, Chronic hepatitis B