西安市超重及肥胖者非酒精性脂肪性肝病患病现状及影响因素

doi:10.12183/j.scjpm.2022.1210

摘要/Abstract

摘要： 目的探讨超重及肥胖者中非酒精性脂肪性肝病（NAFLD）患病现状及影响因素。方法选择2021年在西安市某医院完成健康体检的超重及肥胖者作为研究对象,收集超重及肥胖者的基本信息、生理生化指标及腹部彩超影像学诊断结果,采用描述性方法分析NAFLD患病情况,采用单、多因素分析方法对超重及肥胖者的NAFLD患病影响因素进行分析。结果从12 964名体检人员中获得超重及肥胖体检者共6 351例,其中男性3 325例,占52.35%,女性3 026例,占47.65%。年龄33~76岁,以60~76岁所占比例较高,占37.40%。共有1 222例诊断为NAFLD,患病率为19.24%。其中轻度365例（29.87%）,中度778例（63.67%）,重度79例（6.46%）。多因素Logistic回归分析结果显示男性（OR=2.807）、年龄≥44岁（OR=3.684、4.158）、肥胖（OR=2.177）、SBP异常增高（OR=4.745）、腰围异常（OR=3.102）、ALT异常（OR=2.740）、AST异常（OR=2.726）、GGT异常（OR=2.373）、FBG异常（OR=3.684）、UA异常（OR=3.096）、TG异常（OR=3.490）、TC异常（OR=3.819）、LDL-C异常（OR=3.647）、HDL-C异常（OR=2.807）的体检人群中超重及肥胖者患NAFLD可能性更高。结论体检人群中超重及肥胖者的NAFLD检出率较高,需要尽早给予针对性的干预,部分因素被确定为该人群发生NAFLD的影响因素,这有助于指导干预工作的实施。

关键词: 体检人群, 超重, 肥胖, 非酒精性脂肪性肝病, 肝硬化

Abstract: Objective To investigate the prevalence and influencing factors of non-alcoholic fatty liver disease （NAFLD） in overweight and obese persons. Methods Overweight and obese people who completed a physical examination in a hospital in Xi'an in 2021 were selected. Their basic information, physiological and biochemical information, and diagnosis results of abdominal color doppler ultrasonography were collected. The descriptive method was used to analyze the prevalence of NAFLD in overweight and obese persons, and univariate and multivariate analysis methods were used to analyze the influencing factors of NAFLD. Results A total of 6 351 overweight and obese persons were obtained from 12 964 physical examiners, including 3 325 males （52.35%） and 3 026 females （47.65%）. The age was 33-76 years old, and the proportion of 60-76 years old was higher, accounting for 37.40%. A total of 1 222 cases were diagnosed as NAFLD, with a prevalence rate of 19.24%. Among them, 365 cases were mild （29.87%）, 778 cases were moderate （63.67%）, and 79 cases were severe （6.46%）. Multivariate Logistic regression analysis showed that males （OR＝2.807）, aged 44 and over （OR＝3.684, 4.158）, obesity （OR＝2.177）, abnormally high SBP （OR＝4.745）, abnormal waist circumference （OR＝3.102）, abnormal ALT （OR＝2.740）, abnormal AST （OR＝2.726）, abnormal GGT （OR＝2.373）, abnormal FBG （OR＝3.684）, abnormal UA （OR＝3.096）, abnormal TG （OR＝3.490）, abnormal TC （OR＝3.819）, abnormal LDL-C （OR＝3.647）and abnormal HDL-C（OR＝2.807） were risk factors of NAFLD in overweight and obese persons. Conclusions The prevalence of NAFLD in overweight and obese persons in a physical examination population is high, so targeted intervention is needed as soon as possible. Some factors are identified as the influencing factors of NAFLD in this population, which is helpful to guide the implementation of the intervention.

Key words: Physical examination population, Overweight, Obesity, Non-alcoholic fatty liver disease, Cirrhosis

中图分类号:

R195

查元, 李琳, 李伟民, 范明, 师婷. 西安市超重及肥胖者非酒精性脂肪性肝病患病现状及影响因素[J]. 华南预防医学, 2022, 48(10): 1210-1214.

CHA Yuan, LI Lin, LI Wei-min, FAN Ming, SHI Ting. Prevalence and influencing factors of non-alcoholic fatty liver disease in overweight and obese persons in Xi'an[J]. South China Journal of Preventive Medicine, 2022, 48(10): 1210-1214.

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