澄迈地区中老年女性25-羟维生素D水平及维生素D受体基因多态性与骨密度关联性分析

doi:10.12183/j.scjpm.2023.0709

华南预防医学 ›› 2023, Vol. 49 ›› Issue (6): 709-713.doi: 10.12183/j.scjpm.2023.0709

澄迈地区中老年女性25-羟维生素D水平及维生素D受体基因多态性与骨密度关联性分析

梁定川¹, 张丕军², 王玮¹, 刘强³, 梁尊森⁴

1.澄迈县人民医院,海南澄迈 571900;
2.海南医学院第二附属医院;
3.澄迈县中医院;
4.澄迈县永发卫生院

收稿日期:2023-01-09 出版日期:2023-06-20 发布日期:2023-08-28
作者简介:梁定川（1986—）,男,大学本科,主治医师,研究方向：创伤骨科
基金资助:
海南省卫生计生行业科研项目（19A200113）

Association analysis of 25-hydroxyvitamin D level or vitamin D receptor gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region

LIANG Dingchuan¹, ZHANG Pijun², WANG Wei¹, LIU Qiang³, LIANG Zunsen⁴

1. Chengmai County People's Hospital, Chengmai 571900, China;
2. The Second Affiliated Hospital of Hainan Medical University;
3. Chengmai County Traditional Chinese Medicine Hospital;
4. Yongfa Health Center in Chengmai County

Received:2023-01-09 Online:2023-06-20 Published:2023-08-28

摘要/Abstract

摘要： 目的调查澄迈地区中老年女性血清25-羟维生素D水平及维生素D受体（VDR）基因多态性与骨密度的关联性。方法选取2019年12月至2022年12月在澄迈县人民医院、澄迈县中医院及澄迈县永发卫生院进行健康体检的≥45岁中老年女性作为研究对象,收集研究对象的基线资料,检测其血清25-羟维生素D水平、VDR基因多态性和骨密度,分析VDR基因多态性及25-羟维生素D水平与骨密度的关联性。结果共纳入3 016名中老年女性,年龄45~77岁,平均年龄（60.98±8.46）岁。骨密度异常者1 900例,占63.00%,不同年龄、BMI、是否合并高血压、绝经情况、25-羟维生素D水平等中老年女性骨密度异常率差异均有统计学意义（均P<0.01）。VDR基因多态性检测结果显示,澄迈地区中老年女性VDR基因ApaI、FokI、TaqI位点存在多态性,ApaI、FokI、TaqI位点基因型分别为AA、Aa、aa,FF、Ff、ff,TT、Tt、tt。Logistic回归分析显示,年龄65~77岁（OR=3.931）、BMI超重/肥胖（OR=2.171）、合并高血压（OR=1.634）、绝经（OR=2.413）、25-羟维生素D水平缺乏（OR=3.086）、VDR基因ApaI位点基因型AA型（OR=2.307）、FokI位点基因型ff型（OR=2.494）、TaqI位点基因型TT型（OR=2.784）均与中老年女性骨密度异常有关。结论澄迈地区中老年女性骨密度异常较高,而25-羟维生素D水平及VDR基因多态性与骨密度密切相关。

关键词: 中老年, 女性, 25-羟维生素D, 维生素D受体基因多态性, 骨密度

Abstract: Objective To investigate the association between serum 25-hydroxyvitamin D level or vitamin D receptor （VDR） gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region. Methods Middle-aged and elderly women ≥45 years old who underwent physical examination in Chengmai County People's Hospital, Chengmai County Traditional Chinese Medicine Hospital, and Yongfa Health Center in Chengmai County from December 2019 to December 2022 were selected for this study. Baseline data of the study subjects were collected, and serum 25-hydroxyvitamin D level, VDR gene polymorphism, and bone mineral density were detected. The association between VDR gene polymorphism or 25-hydroxyvitamin D level and bone mineral density was analyzed. Results A total of 3 016 middle-aged and elderly women were included, aged 45-77 years, with an average age of （60.98±8.46） years. There were 1 900 cases with abnormal bone mineral density, accounting for 63.00%. There were significant differences in bone mineral density among different age, BMI, hypertension, menopause, and 25-hydroxyvitamin D level （all P<0.01）. VDR gene polymorphism detection results showed that there were polymorphisms at ApaI, FokI, and TaqI loci of VDR genes in middle-aged and elderly women in Chengmai region, and the genotypes of ApaI, FokI, and TaqI loci were AA/Aa/aa, FF/Ff/ff, TT/Tt/tt, respectively. Logistic regression analysis showed that aged 65 and over （OR=3.931）, BMI overweight/obesity （OR=2.171）, combined hypertension （OR=1.634）, menopause （OR=2.413）, 25-hydroxyvitamin D deficiency （OR=3.086）, VDR ApaI genotype AA （OR=2.307）, FokI genotype ff （OR=2.494）, and TaqI genotype TT （OR=2.784） were associated with abnormal bone mineral density in middle-aged and elderly women. Conclusion The incidence of abnormal bone mineral density is high in middle-aged and elderly women in Chengmai region, and the 25-hydroxyvitamin D level and VDR gene polymorphism are closely related to bone mineral density.

Key words: Middle-aged and elderly, Woman, 25-hydroxyvitamin D, Vitamin D receptor gene polymorphism, Bone mineral density

中图分类号:

R173

梁定川, 张丕军, 王玮, 刘强, 梁尊森. 澄迈地区中老年女性25-羟维生素D水平及维生素D受体基因多态性与骨密度关联性分析[J]. 华南预防医学, 2023, 49(6): 709-713.

LIANG Dingchuan, ZHANG Pijun, WANG Wei, LIU Qiang, LIANG Zunsen. Association analysis of 25-hydroxyvitamin D level or vitamin D receptor gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region[J]. South China Journal of Preventive Medicine, 2023, 49(6): 709-713.

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澄迈地区中老年女性25-羟维生素D水平及维生素D受体基因多态性与骨密度关联性分析

Association analysis of 25-hydroxyvitamin D level or vitamin D receptor gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region

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