Oz病毒研究进展及其公共卫生防控策略

doi:10.12183/j.scjpm.2025.1103

摘要/Abstract

摘要： 2023年6月,日本报告了全球首例人类感染Oz病毒并导致死亡的病例,引发了国际社会的广泛关注。Oz病毒是一种通过蜱虫传播的虫媒病毒,于2018年首次在日本龟形花蜱内被发现。鉴于蜱虫在全球范围内的广泛分布,该病毒可能对全球公共卫生构成潜在威胁。目前,关于Oz病毒的科学研究尚处于初步阶段。本文旨在综述Oz病毒的最新研究进展,并基于现有数据探讨相应的公共卫生防控策略,以期为未来的深入研究及有效防治提供科学参考。

关键词: Oz病毒, 病毒传播, 抗病毒药物, 疫苗

中图分类号:

R373

陈至里, 蒲俏虹, 纪洵敏, 杨代晓, 张磊, 梁旭霞, 彭拓华. Oz病毒研究进展及其公共卫生防控策略[J]. 华南预防医学, 2025, 51(10): 1103-1106.

参考文献

[1] 新华网. 日本报告全球首例人感染并死于Oz病毒的病例[EB/OL]. (2023-06-23)[2024-07-20]. https://www.news.cn/world/2023-06/23/c_1129713559.htm.
[2] Ejiri H, Lim CK, Isawa H, et al.Characterization of a novel thogotovirus isolated from Amblyomma testudinarium ticks in Ehime, Japan: A significant phylogenetic relationship to Bourbon virus[J]. Virus Res, 2018, 249: 57-65.
[3] Akter L, Matsumura R, Kobayashi D, et al.Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus[J]. Virology, 2025, 603: 110410.
[4] Xue L, Chang T, Li Z, et al.Cryo-EM structures of Thogotovirus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses[J]. Nat Commun, 2024, 15(1): 4620.
[5] Fuchs J, Lamkiewicz K, Kolesnikova L, et al.Comparative study of ten thogotovirus isolates and their distinct in vivo characteristics[J]. J Virol, 2022, 96(5): e0155621.
[6] Dick A, Mikirtumov V, Fuchs J, et al.Structural characterization of thogotovirus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly[J]. Structure, 2024, 32(8): 1068-1078.
[7] Matsuu A, Tatemoto K, Ishijima K, et al.Oz virus infection in 6 animal species, including macaques, bears, and companion animals, Japan[J]. Emerg Infect Dis, 2025, 31(4): 720-727.
[8] Chao LL, Lu CW, Lin YF, et al.Molecular and morphological identification of a human biting tick, Amblyomma testudinarium (Acari: Ixodidae), in Taiwan[J]. Exp Appl Acarol, 2017, 71(4): 1-14.
[9] 吴婷婷. 四种蜱虫线粒体全基因组扩增与森林革蜱基因多态性分析[D]. 大庆:黑龙江八一农垦大学,2022.
[10] Tran NTB, Shimoda H, Ishijima K, et al.Zoonotic infection with Oz virus, a novel thogotovirus[J]. Emerg Infect Dis, 2022, 28(2): 436-439.
[11] Azagi T, Hoeve-Bakker BJA, Jonker M, et al.Technical evaluation of qPCR multiplex assays for the detection of ixodes ricinus-borne pathogens[J]. Microorganisms, 2022, 10(11): 2222.
[12] 崔濮凡,张永英,钟翠红,等. 蜱传病原体的危害及其与媒介蜱相互作用的研究进展[J]. 中国兽医杂志,2024,60(1):94-101.
[13] 毛锐坤,汤莉,彭晓放,等. 全球化背景下主要蚊媒传染病的流行趋势与防控[J]. 现代预防医学,2025,52(10):1729-1734,1741.
[14] Wagner V, Sabachvili M, Bendl E, et al.The antiviral activity of equine Mx1 against Thogoto virus is determined by the molecular structure of its viral specificity region[J]. J VIROL, 2023, 97(2): e0193822.
[15] Ahata B, Akçapınar GB.CCHFV vaccine development, current challenges, limitations, and future directions[J]. Front Immunol, 2023, 14: 1238882.
[16] Hao S, Ning K, Wang X, et al.Establishment of a replicon reporter of the emerging tick-borne bourbon virus and use it for evaluation of antivirals[J]. Front Microbiol, 2020, 11: 572631.
[17] Engdahl TB, Binshtein E, Brocato RL, et al.Antigenic mapping and functional characterization of human new world Hantavirus neutralizing antibodies[J]. eLife, 2023, 12: e81743.
[18] Li L, Chong T, Peng L, et al.Neutralizing monoclonal antibodies against the Gc fusion loop region of crimean-congo Hemorrhagic fever virus[J]. PLoS Pathog, 2024, 20(2): e1011948.
[19] Lu J, Liu J, Wu Y, et al.A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses[J]. J Virol, 2024, 98(7): e0076924.
[20] Qu Q, Hao P, Xu W, et al.A vaccine of SARS-CoV-2 S protein RBD induces protective immunity[J]. Int J Mol Sci, 2022, 23(22): 13716.
[21] 马林,鞠金鑫,李琳,等. 托高土病毒核蛋白的异源表达、纯化与结晶[J]. 济南大学学报(自然科学版),2024,38(6):707-712.
[22] Almanaa TN.Reverse vaccinology integrated with biophysics techniques for designing a peptide-based subunit vaccine for Bourbon virus[J]. Bioengineering (Basel), 2024, 11(11): 1056.
[23] Pirincal A, Doymaz MZ.The role of nucleocapsid protein (NP) in the immunology of crimean-congo hemorrhagic fever virus (CCHFV)[J]. Viruses, 2024, 16(10): 1547.
[24] Zhou Y, Li T, Zhang Y, et al.BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly[J]. PLoS Pathog, 2024, 20(3): e1012110.
[25] Mizuta S, Otaki H, Ishikawa T, et al.Lead optimization of influenza virus RNA polymerase inhibitors targeting PA-PB1 interaction[J]. J Med Chem, 2022, 65(1): 369-385.
[26] Thamamongood T, Jengarn J, Muangsanit P, et al.Pseudotyped zoonotic thogotoviruses exhibit broad entry range in mammalian cells[J]. Virology, 2024, 589: 109914.
[27] Wang J, Zhang Y, Sun L, et al.Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein[J]. Emerg Microbes Infect, 2025, 14(1): 2477645.
[28] Yu C, Wang G, Liu Q, et al.Host antiviral factors hijack furin to block SARS-CoV-2, Ebola virus, and HIV-1 glycoproteins cleavage[J]. Emerg Microbes Infect, 2023, 12(1): 2164742.
[29] Zhang Z, Aziati ID, Nipper T, et al.ANP32 proteins from ticks and vertebrates are key host factors for replication of bourbon virus across species[J]. J Virol, 2025, 99(6): e0052225.