缺血性卒中患者膳食维生素摄入与颈动脉狭窄的关联研究

doi:10.12183/j.scjpm.2021.0030

摘要/Abstract

摘要： 目的评估缺血性卒中患者膳食维生素摄入与颈动脉狭窄之间的关系。方法连续纳入2016年1月至2019年12月在金陵临床医学院住院的缺血性卒中患者,采用食物调查问卷评估膳食维生素摄入水平,颈动脉计算机断层血管造影（CTA）评估颈动脉狭窄率,并检测血中性粒细胞计数、淋巴细胞计数、同型半胱氨酸（Hcy）、C反应蛋白（CRP）、糖化血红蛋白（HbA1c）水平。采用有序Logistic回归分析评估膳食维生素摄入与颈动脉狭窄之间的关系。结果共纳入628例缺血性卒中患者,平均年龄为（64.8±10.9）岁,检测到颈动脉狭窄者390例（占62.1%）。有序Logistic回归分析显示,维生素B₃（OR=0.954,95% CI：0.913~0.997）、维生素B₆（OR=0.634,95%CI：0.407~0.989）、维生素B₁₂（OR=0.796,95%CI：0.663~0.956）是颈动脉狭窄程度的独立预测因素。结论缺血性卒中患者膳食维生素摄入水平可能会影响颈动脉狭窄程度,缺血性卒中患者维持适量的维生素B₃、B₆、B₁₂摄入水平可能有利于延缓动脉粥样硬化的发生和发展。

关键词: 缺血性卒中, 膳食, 维生素, 动脉粥样硬化

Abstract: Objective To investigate the association between dietary vitamin intake and carotid artery stenosis in patients with ischemic stroke. Methods Patients with ischemic stroke hospitalized in Jinling Hospital from January 2016 to December 2019 were included. Dietary vitamin intake was assessed with food questionnaire. Carotid artery stenosis was evaluated with computed tomography angiography （CTA）. Blood neutrophil count, lymphocyte count, serum homocysteine （Hcy）, C-reactive protein （CRP）, and hemoglobin A1c（HbA1c） were detected. Ordered Logistic regression analysis was used to evaluate the association between dietary vitamin intake and carotid artery stenosis. Results A total of 628 patients with ischemic stroke were enrolled, with an average age of （64.8±10.9） years, 390 （62.1%） were detected with carotid artery stenosis. Ordered Logistic regression showed that vitamin B₃ （OR=0.954, 95% CI： 0.913-0.997）, vitamin B₆ （OR=0.634, 95% CI： 0.407-0.989） and vitamin B₁₂ （OR=0.796, 95%CI： 0.663-0.956） were independent predicators of the degree of carotid artery stenosis. Conclusion Dietary vitamin intake in patients with ischemic stroke may influence the degree of carotid artery stenosis. Maintaining adequate intake of vitamin B₃, B₆ and B₁₂ may be beneficial for preventing development of atherosclerosis.

Key words: Ischemic stroke, Diet, Vitamin, Atherosclerosis

中图分类号:

R151.4+3

夏亚倩, 彭敏, 贾雪蓉, 徐格林. 缺血性卒中患者膳食维生素摄入与颈动脉狭窄的关联研究[J]. 华南预防医学, 2021, 47(1): 30-34.

XIA Ya-qian, PENG Min, JIA Xue-rong, XU Ge-lin. Association between dietary vitamin intake and carotid artery stenosis in patients with ischemic stroke[J]. South China Journal of Preventive Medicine, 2021, 47(1): 30-34.

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