华南预防医学 ›› 2021, Vol. 47 ›› Issue (9): 1155-1161.doi: 10.12183/j.scjpm.2021.1155
李小毛, 李依芬, 万璟, 杨越波, 张宇
收稿日期:
2021-03-28
发布日期:
2021-10-18
通讯作者:
李小毛,E-mail:lixmao@mail.sysu.edu.cn
LI Xiao-mao, LI Yi-fen, WAN Jing, YANG Yue-bo, ZHANG Yu
Received:
2021-03-28
Published:
2021-10-18
摘要: 人乳头瘤病毒(HPV)疫苗接种是子宫颈癌防控的重要措施之一。通过综合考虑HPV疫苗接种的有效性、安全性、成本效益等多方面因素,专家强烈推荐青春前期(9~14岁)女性作为重点目标人群应优先接种HPV疫苗,提高重点目标人群HPV疫苗免疫覆盖率,以达到子宫颈癌一级预防策略的最佳效果。
中图分类号:
李小毛, 李依芬, 万璟, 杨越波, 张宇. 青春前期女性接种人乳头瘤病毒疫苗专家共识[J]. 华南预防医学, 2021, 47(9): 1155-1161.
LI Xiao-mao, LI Yi-fen, WAN Jing, YANG Yue-bo, ZHANG Yu. Expert consensus on human papillomavirus vaccination for prepubertal girls[J]. South China Journal of Preventive Medicine, 2021, 47(9): 1155-1161.
[1] Gultekin M, Ramirez PT, Broutet N, et al.World Health Organization call for action to eliminate cervical cancer globally[J]. Int J Gynecol Cancer,2020,30(4): 426-427. [2] Zhu B, Liu Y, Zuo T, et al.The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women[J].Cancer Med,2019,8(11):5373-5385. [3] Wang R, Guo X, Wisman GBA, et al.Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China[J]. BMC Infect Dis,2015,15(1):257. [4] Secor-Turner M, Kugler K, Bearinger LH, et al.A global perspective of adolescent sexual and reproductive health: context matters[J]. Adolescent Medicine (Elk Grove Village, Ill.),2009,20(3):1005. [5] 国家卫生计生委家庭司. 中国家庭发展报告2015[M]. 北京:中国人口出版社,2015:83-84. [6] Shu C, Fu A, Lu J, et al.Association between age at first sexual intercourse and knowledge, attitudes and practices regarding reproductive health and unplanned pregnancy: A cross-sectional study[J]. Public Health,2016,135:104-113. [7] Vinodhini K, Shanmughapriya S, Das BC, et al.Prevalence and risk factors of HPV infection among women from various provinces of the world[J]. Arch Gynecol Obstet,2012,285(3):771-777. [8] Patel A, Galaal K, Burnley C, et al.Cervical cancer incidence in young women: a historical and geographic controlled UK regional population study[J]. Br J Cancer,2012,106(11):1753-1759. [9] 孟令昊,胥秋艳,李科,等. 1990—2019年中国女性宫颈癌疾病负担变化的分析[J]. 中国循证医学杂志,2021,21(6):648-653. [10] Li X, Zheng R, Li X, et al.Trends of incidence rate and age at diagnosis for cervical cancer in China, from 2000 to 2014[J]. Chin J Cancer Res,2017,29(6):477-486. [11] Cai HB, Liu XM, Huang Y, et al.Trends in cervical cancer in young women in Hubei, China[J]. Int J Gynecol Cancer,2010,20(7):1240-1243. [12] WHO. Human papillomavirus vaccines: WHO position paper, May 2017-Recommendations[J]. Vaccine,2017,35(43):5753-5755. [13] No authors listed.Human papillomavirus vaccination: ACOG committee opinion summary, Number 809[J]. Obstet Gynecol,2020,136(2):435-436. [14] Xia C, Xu X, Zhao X, et al.Effectiveness and cost-effectiveness of eliminating cervical cancer through a tailored optimal pathway: A modeling study[J]. BMC Med,2021,19(1):62. [15] Hu Y, Guo M, Li C, et al.Immunogenicity noninferiority study of 2 doses and 3 doses of an [16] Zhu F, Li J, Hu Y, et al.Immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in healthy Chinese girls and women aged 9 to 45 years[J]. Hum Vaccin Immunother,2014,10(7):1795-1806. [17] Puthanakit T, Huang LM, Chiu CH, et al.Randomized open trial comparing 2-dose regimens of the human papillomavirus 16/18 AS04-adjuvanted vaccine in girls aged 9-14 years versus a 3-dose regimen in women aged 15-25 years[J]. J Infect Dis,2016,214(4):525-536. [18] Li R, Li Y, Radley D, et al.Safety and immunogenicity of a vaccine targeting human papillomavirus types 6, 11, 16 and 18: A randomized, double-blind, placebo-controlled trial in Chinese males and females[J]. Vaccine,2012,30(28):4284-4291. [19] Dobson SR, Mcneil S, Dionne M, et al.Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: A randomized clinical trial[J]. JAMA,2013,309(17):1793-1802. [20] Iversen O, Miranda MJ, Ulied A, et al.Immunogenicity of the 9-valent HPV vaccine using 2-Dose regimens in girls and boys vs a 3-dose regimen in women[J]. JAMA,2016,316(22):412-413. [21] Mélanie D, élodie B, Norma P, et al.Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: Updated systematic review and meta-analysis[J]. Lancet,2019,394(10197):497-509. [22] Lei J, Ploner A, Elfström KM, et al.HPV vaccination and the risk of invasive cervical cancer[J]. N Engl J Med,2021,76(1):1340-1348. [23] Madleen O, Susanne KK, Christian D, et al.The impact of HPV multi-cohort vaccination: Real-world evidence of faster control of HPV-related morbidity[J]. Vaccine,2020,38(6):1345-1351. [24] Folschweiller N, Behre U, Dionne M, et al.Long-term cross-reactivity against nonvaccine human papillomavirus types 31 and 45 after 2- or 3-dose schedules of the AS04-adjuvanted human HPV-16/18 vaccine[J]. J Infect Dis,2019,219(11):1799-1803. [25] Aregay M, Shkedy Z, Molenberghs G, et al.Model-based estimates of long-term persistence of induced HPV antibodies: A flexible subject-specific approach[J]. J Biopharm Stat,2013,23(6):1228-1248. [26] David MP, Van Herck K, Hardt K, et al.Long-term persistence of anti-HPV-16 and -18 antibodies induced by vaccination with the AS04-adjuvanted cervical cancer vaccine: modeling of sustained antibody responses[J]. Gynecol Oncol,2009,115(3 Suppl):S1-S6. [27] Ferris DG, Samakoses R, Block SL, et al.4-Valent human papillomavirus (4vHPV) vaccine in preadolescents and adolescents after 10 years[J]. Pediatrics,2017,140(6): e20163947. [28] Toh ZQ.Evaluation of long-term immunological responses following reduced-dose quadrivalent human papillomavirus vaccine schedules in Fiji[D]. Australia:University of Melbourne,2017. [29] Olsson SE, Restrepo JA, Reina JC, et al.Long-term immunogenicity, effectiveness, and safety of nine-valent human papillomavirus vaccine in girls and boys 9 to 15 years of age: Interim analysis after 8 years of follow-up[J]. Papillomavirus Res,2020,10:100203. [30] Bornstein J, Roux S, Kjeld PL, et al.Three-year follow-up of 2-dose versus 3-dose HPV vaccine[J]. Pediatrics,2021,147(1): e20194035. [31] Einstein MH, Levin MJ, Chatterjee A, et al.Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18-45 years: Follow-up through month 48 in a phase III randomized study[J]. Hum Vaccin Immunother,2014,10(12):3455-3465. [32] Reiter PL, Brewer NT, Gottlieb SL, et al.How much will it hurt? HPV vaccine side effects and influence on completion of the three-dose regimen[J]. Vaccine,2009,27(49):6840-6844. [33] Joura EA, Giuliano AR, Iversen OE, et al.A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women[J]. N Engl J Med,2015,372(8):711-723. [34] 陈桂珍. 由大肠杆菌制备的人乳头瘤病毒(16型和18型)二价疫苗的免疫原性和安全性:Ⅱ期临床试验[J]. 微生物学免疫学进展,2016,44(5):85. [35] CDC. HPV vaccine safety[EB/OL].(2021-07-23)[2021-09-09].https://www.cdc.gov/vaccinesafety/vaccines/hpv/hpv-safety-faqs.html,2020. [36] Tiffany AS, Paige L, Jorge A, et al.Safety of bivalent human papillomavirus vaccine in the US vaccine adverse event reporting system (VAERS), 2009-2017[J]. Br J Clin Pharmacol,2018,84(12): 2928-2932. [37] Jorge EA, Theresa H, Maria C, et al.Post-licensure safety monitoring of quadrivalent human papillomavirus vaccine in the Vaccine Adverse Event Reporting System (VAERS), 2009-2015[J]. Vaccine,2018,36(13): 1781-1788. [38] Phillips A, Patel C, Pillsbury A, et al.Safety of human papillomavirus vaccines: An updated review[J]. Drug Saf,2018,41(4):329-346. [39] 乔友林,吴婷,李荣成,等. 双价人乳头瘤病毒疫苗(大肠杆菌)的有效性研究:一项随机对照临床试验的中期分析[J]. 中国妇产科临床杂志,2020,21(6):581-584. [40] Edson DM, Stan LB, Daron F, et al.Safety profile of the 9-valent HPV vaccine: A combined analysis of 7 phase III clinical trials[J]. Pediatrics,2016,138(2):1-17. [41] Vesikari T, Brodszki N, van Damme P, et al. A randomized, double-blind, phase iii study of the immunogenicity and safety of a 9-valent human papillomavirus l1 virus-like particle vaccine (V503) versus Gardasil® in 9-15-year-old girls[J]. Pediatr Infect Dis J,2015,34(9):992-998. [42] No authors listed.Meeting of the global advisory committee on vaccine safety, 7-8 June 2017[J]. Wkly Epidemiol Rec,2017,92(28):393-402. [43] Ojha RP, Jackson BE, Tota JE, et al.Guillain-Barre syndrome following quadrivalent human papillomavirus vaccination among vaccine-eligible individuals in the United States[J]. Hum Vaccin Immunother,2014,10(1):232-237. [44] Miranda S, Chaignot C, Collin C, et al.Human papillomavirus vaccination and risk of autoimmune diseases: A large cohort study of over 2million young girls in France[J]. Vaccine,2017,35(36):4761-4768. [45] Vielot NA, Becker-Dreps S.Hazard of complex regional pain syndrome following human papillomavirus vaccination among adolescent girls in the United States: A case-cohort analysis of insurance claims data[J]. Expert Opin Drug Saf,2020,19(1):107-112. [46] 汪安石,黄演林,刘畅,等. (围)妊娠期HPV疫苗接种对后代出生缺陷发生风险的影响[J]. 中国产前诊断杂志(电子版),2020,12(3):34-39. [47] 赖婷,王艳萍,李小洪,等. 预防性接种人乳头瘤病毒疫苗对妊娠结局的影响[J]. 中华妇幼临床医学杂志(电子版),2018,14(6):621-628. [48] 郭建铭,郑斌,李娜,等. 人乳头瘤病毒疫苗预防中国女性宫颈癌药物经济学研究的系统评价[J]. 中国现代应用药学,2021,38(4):445-452. [49] European Medicines Agency.Assessment report cervarix[EB/OL].(2013-01-01)[2021-09-09].https://www.ema.europa.eu/en/medicines/human/EPAR/cervarix,2013. [50] Aljunid S, Maimaiti N, Nur AM, et al.Cost-effectiveness of HPV vaccination regime:Comparing twice versus thrice vaccinations dose regime among adolescent girls in Malaysia[J]. BMC Public Health,2016,16:71. [51] Prinja S, Bahuguna P, Faujdar DS, et al.Cost-effectiveness of human papillomavirus vaccination for adolescent girls in Punjab state: Implications for India's universal immunization program[J]. Cancer,2017,123(17):3253-3260. [52] Phua LC, Choi H, Wu J, et al.Cost-effectiveness analysis of the nonavalent human papillomavirus vaccine for the prevention of cervical cancer in Singapore[J]. Vaccine,2021,39(16):2255-2263. [53] Mahumud RA, Gow J, Alam K, et al.Cost-effectiveness of the introduction of two-dose bi-valent (Cervarix) and quadrivalent (Gardasil) HPV vaccination for adolescent girls in Bangladesh[J]. Vaccine,2020,38(2):165-172. [54] Mennini FS, Bonanni P, Bianic F, et al.Cost-effectiveness analysis of the nine-valent HPV vaccine in Italy[J]. Cost Eff Resour Alloc,2017,15:11. [55] Zou Z, Fairley CK, Ong JJ, et al.Domestic HPV vaccine price and economic returns for cervical cancer prevention in China: A cost-effectiveness analysis[J]. Lancet Glob Health,2020,8(10):e1335-e1344. [56] 徐小倩,由婷婷,胡尚英,等. 全球人乳头瘤病毒疫苗接种指南制定现状的系统综述[J]. 中华医学杂志,2021,101(24):1890-1898. [57] WHO.Vaccine in national immunization program update[R]. Geneva:WHO:2020. [58] Bruni L, Saura A, Montoliu A, et al.HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010-2019[J]. Prev Med,2020,144:106399. [59] 冯雪娇,侯海龙,喻琼,等. 我国宫颈癌疫苗市场分析及对策研究[J]. 中国生物工程杂志,2020,40(11):96-101. [60] 史金晶,张肖肖,郑徽,等. 中国大陆青少年家长人乳头瘤病毒疫苗认知度和接受度Meta分析[J]. 中国疫苗和免疫,2019,25(4):464-470. [61] Mcclymont E, Lee M, Raboud J, et al.The efficacy of the quadrivalent human papillomavirus vaccine in girls and women living with human immunodeficiency virus[J]. Clin Infect Dis,2019,68(5):788-794. [62] Macintyre CR, Shaw PJ, Mackie FE, et al.Long term follow up of persistence of immunity following quadrivalent Human Papillomavirus (HPV) vaccine in immunocompromised children[J]. Vaccine,2019,37(37):5630-5636. [63] Ingrid HRG, Natalia FP, Aline L, et al.Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with childhood systemic lupus erythematosus: A real-world interventional multi-centre study[J]. Lupus,2020,29(8): 096120332092840. [64] Praditpornsilpa K, Kingwatanakul P, Deekajorndej T, et al.Immunogenicity and safety of quadrivalent human papillomavirus types 6/11/16/18 recombinant vaccine in chronic kidney disease stage IV, V and VD[J]. Nephrol Dial Transplant,2017,32(1):132-136. |
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