流感病毒空气传播和扩散的研究进展

doi:10.12183/j.scjpm.2023.1000

摘要/Abstract

摘要： 流感病毒是现今世界上传播较为迅速的呼吸道病毒之一,主要以飞沫传播和气溶胶传播为主。目前针对流感病毒空气传播的研究主要以病毒学领域的病毒稳定性研究和工程学领域的呼吸飞沫的运动和扩散研究为主。然而,流感病毒的空气传播需要满足人体呼出携带病毒颗粒的飞沫或气溶胶,其次是载体颗粒中的病毒到达易感宿主发生感染之前必须具有感染性,单靠病毒学或工程学某一领域难以全面系统地了解流感病毒在空气中传播扩散机制。本研究将总结和分析当前流感病毒室内传播和扩散的研究情况,并为今后相关领域的深入研究提供思路。

中图分类号:

R183.3

邓慧诗, 谢家敏, 杨康, 黄鑫鑫, 武婕. 流感病毒空气传播和扩散的研究进展[J]. 华南预防医学, 2023, 49(8): 1000-1004.

参考文献

[1] Nogales A, DeDiego ML. Influenza virus and vaccination[J]. Pathogens, 2020, 9(3):220.
[2] Krammer F, Smith GJD, Fouchier RAM, et al.Influenza[J]. Nat Rev Dis Primers 2018, 4(1): 3.
[3] Cantan B, Luyt CE, Martin-Loeches I. Influenza infections and emergent viral infections in intensive care unit[J]. Semin Resp Crit Care, 2019, 40(4): 488-497.
[4] Vemula SV, Zhao J, Liu J, et al.Current approaches for diagnosis of influenza virus infections in humans[J]. Viruses, 2016, 8(4):96.
[5] Paules C, Subbarao K.Influenza[J]. Lancet,2017,390(10095):697-708.
[6] Richard M, Fouchier RAM.Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential[J].FEMS Microbiol Rev,2015,40(1):68-85.
[7] Ducatez MF, Webster RG, Webby RJ.Animal influenza epidemiology[J].Vaccine,2008,26(Suppl 4): D67-D69.
[8] Bouvier NM, Lowen AC.Animal models for influenza virus pathogenesis and transmission[J]. Viruses, 2010, 2(8): 1530-1563.
[9] Ravina, Manjeet, Mohan H, et al. A changing trend in diagnostic methods of Influenza A (H3N2) virus in human: A review[J].3 Biotech,2021,11(2): 87.
[10] Caini S, Kusznierz G, Garate VV, et al.The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century[J].PLoS One,2019,14(9):e0222381.
[11] Sederdahl BK, Williams JV.Epidemiology and clinical characteristics of influenza C virus[J]. Viruses,2020,12(1):89.
[12] WHO. Influenza (Seasonal) [EB/OL] (2023-01-12)[2023-01-27]. https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
[13] Steel J, Palese P, Lowen AC.Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain[J].J Virol, 2011,85(3):1400-1402.
[14] Lowen AC, Mubareka S, Steel J, et al.Influenza virus transmission is dependent on relative humidity and temperature[J].PLoS Pathog,2007,3(10): 1470-1476.
[15] Zhou J, Wei J, Choy KT, et al.Defining the sizes of airborne particles that mediate influenza transmission in ferrets[J].Proc Natl Acad Sci USA,2018,115(10):E2386-E2392.
[16] Pyankov OV, Pyankova OG, Agranovski IE.Inactivation of airborne influenza virus in the ambient air[J]. J Aerosol Sci, 2012, 53: 21-28.
[17] Kormuth KA, Lin K, Qian Z, et al.Environmental persistence of influenza viruses is dependent upon virus type and host origin[J].mSphere,2019, 4(4):e00552-00571.
[18] Peci A, Winter AL, Li Y, et al.Effects of absolute humidity, relative humidity, temperature, and wind speed on influenza activity in Toronto, Ontario, Canada[J]. Appl Environ Microbiol,2019, 85(6):e02426-e02444.
[19] Yamaya M, Nishimura H, Kalonji NL, et al.Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures[J].Heliyon,2019,5(2):e01149.
[20] Pica N, Chou YY, Bouvier NM, et al.Transmission of influenza B viruses in the guinea pig[J]. J Virol,2012,86(8):4279-4287.
[21] Shaman J, Kohn M.Absolute humidity modulates influenza survival, transmission, and seasonality[J]. Proc Natl Acad Sci USA, 2009, 106: 3243-3248.
[22] Polozov IV, Bezrukov L, Gawrisch K, et al.Progressive ordering with decreasing temperature of the phospholipids of influenza virus[J].Nat Chem Biol,2008,4(4):248-255.
[23] Bozic A, Kanduc M.Relative humidity in droplet and airborne transmission of disease[J].J Biol Phys,2021,47(1):1-29.
[24] Nikitin N, Petrova E, Trifonova E, et al.Influenza virus aerosols in the air and their infectiousness[J]. Adv Virol, 2014,2014:859090.
[25] Doremalen NV, Bushmaker T, Munster VJ.Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions[J].Euro Surveill,2013, 18(38):20590.
[26] Kormuth KA, Lin K, Prussin AJ, et al.Influenza virus infectivity is retained in aerosols and droplets independent of relative humidity[J].J Infect Dis,2018,218(5):739-747.
[27] Yang X, Ou C, Yang H, et al.Transmission of pathogen-laden expiratory droplets in a coach bus[J].J Hazard Mater,2020,397:122609.
[28] Ahlawat A, Mishra SK, Herrmann H, et al.Impact of chemical properties of human respiratory droplets and aerosol particles on airborne viruses' viability and indoor transmission[J]. Viruses,2022,14(7):1497.
[29] Lin K, Marr LC.Humidity-dependent decay of viruses, but not bacteria, in aerosols and droplets follows disinfection kinetics[J].EST,2020,54(2):1024-1032.
[30] Gralton J, Tovey E, McLaws ML, et al. The role of particle size in aerosolised pathogen transmission: A review[J].J Infect,2011,62(1):1-13.
[31] 陈雪琴,李姗,张明顺,等.生物气溶胶研究进展[J].南京医科大学学报(自然科学版), 2020,40(6): 783-787,792.
[32] WHO. Infection prevention and control of epidemic-and pandemic-prone acute respiratory infections in health care[M].World Health Organization,2014.
[33] Qian H, Miao T, Liu L, et al.Indoor transmission of SARS-CoV-2[J].Indoor Air,2021,31(3): 639-645.
[34] Lommel M, Froese V, Sieber M, et al.Novel measurement system for respiratory aerosols and droplets in indoor environments[J].Indoor Air, 2021,31(6):1860-1873.
[35] 杜茜,温占波,李劲松.病毒气溶胶飞沫在室内环境中传播扩散机制的研究进展[J].军事医学,2021,35(8):631-633,638.
[36] 吴彦,王旭初,王兵,等.空气中流感病毒气溶胶采样技术研究进展[J].中国卫生检验杂志, 2019,29(11): 1406-1409.
[37] Lindsley WG, Pearce TA, Hudnall JB, et al.Quantity and size distribution of cough-generated aerosol particles produced by influenza patients during and after illness[J].J Occupa Environ Hyg,2012,9(7): 443-449.
[38] Brooks JT, Butler JC.Effectiveness of mask wearing to control community spread of SARS-CoV-2[J].JAMA,2021,325(10): 998-999.
[39] Li Y, Leung GM, Tang JW, et al.Role of ventilation in airborne transmission of infectious agents in the built environment - a multidisciplinary systematic review[J].Indoor Air,2007,17(1): 2-18.
[40] Brankston G, Gitterman L, Hirji Z, et al.Transmission of influenza A in human beings[J].Lancet Infect Dis,2007,7(4): 257-265.
[41] Tang JW, Li Y.Transmission of influenza A in human beings[J].Lancet Infect Dis,2007,7(12):758.
[42] Abkarian M, Stone HA.Stretching and break-up of saliva filaments during speech: A route for pathogen aerosolization and its potential mitigation[J].Phys Rev Fluids,2020,5(10):102301-102310.
[43] Guo Y, Ou JJ, Liu CY, et al.Deposition of droplets from the trachea or bronchus in the respiratory tract during exhalation: A steady-state numerical investigation[J].Aerosol Sci Technol, 2020, 54(8):1-11.
[44] Yan J, Grantham M, Pantelic J, et al.Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community[J].Proc Natl Acad Sci USA,2018,115(5):1081-1086.
[45] Asadi S, Wexler AS, Cappa CD, et al.Aerosol emission and superemission during human speech increase with voice loudness[J].Sci Rep,2019, 9(1):2348.
[46] Yang T, Clements-Croome DJ. Natural ventilation in built environment[J].Sustain Built Environ, 2020: 431-464.
[47] Izadyar N, Miller W.Ventilation strategies and design impacts on indoor airborne transmission:A review[J]. Build Environ, 2022, 218: 109158.
[48] Yoon GY, Lee SJ, Kwon H, et al.Effect of flow structures on natural ventilation performance in office model[J]. J Vis (Tokyo), 2022(2):289-298.
[49] Xu R, Wu F, Li X, et al.Numerical comparison of ventilation modes on the transmission of coughing droplets in a train compartment[J].J Wind Eng Ind Aerod, 2022,231(1): 105240.
[50] Sussman RA, Golberstein E, Polosa R.Analytic modeling and risk assessment of aerial transmission of SARS-CoV-2 virus through vaping expirations in shared micro-environments[J]. Eviron Sci Pollut R, 2022, 29(55): 83020-83044.
[51] Wang B, Wu H, Wan XF.Transport and fate of human expiratory droplets-A modeling approach[J]. Phys Fluids,2020, 32(8): 083307.
[52] Robey AJ, Fierce L.Sensitivity of airborne transmission of enveloped viruses to seasonal variation in indoor relative humidity[J].Int Commun Heat Mass Transf,2022, 130:105747-105747.
[53] Wei J, Zhu S, He F, et al.Numerical investigation of airborne transmission of respiratory infections on the subway platform[J]. Geosci Front, 2022, 13(6):101384.
[54] Liu L, Li Y, Nielsen PV, et al.Short-range airborne transmission of expiratory droplets between two people[J].Indoor Air,2017,27(2):452-462.