关键词: 脑梗死, 高血压, 脂肪细胞因子, 颈动脉斑块, 预后

Abstract: Objective To explore the correlation between serum adipocytokines and prognosis of cerebral infarction complicated with hypertension. Methods The patients with first-onset cerebral infarction complicated with hypertension treated in a hospital in Haikou from February 2018 to January 2021 were selected as the research object （cerebral infarction complicated with hypertension group）. At the same time, according to the same gender and age ± 3 years, the inpatients with cerebral infarction in the same hospital, the hypertensive patients in the hypertension clinic and the physical examination person in the healthy physical examination center were matched 1∶1 as the cerebral infarction group, the hypertension group and the healthy control group. Fasting venous blood was collected to detect the levels of visfatin, adiponectin （APN）, omentin-1 and leptin. The properties of carotid artery were measured by ultrasonic detector in the two groups other than the healthy control group and the hypertension group. The prognosis of patients with cerebral infarction complicated with hypertension was evaluated by modified Rankin Scale （MRS）. Descriptive epidemiological analysis method was used to analyze the relevant indexes of the four groups. Results A total of 248 patients with cerebral infarction complicated with hypertension were included in this study, including 148 males and 100 females, with an average age of （60.96 ± 4.77） years. There were 250 cases, 253 cases and 253 persons in cerebral infarction group, hypertension group and healthy control group respectively. There was no significant difference in gender distribution and age among the four groups （all P>0.05）. The levels of blood visfatin and leptin in the cerebral infarction complicated with hypertension group were higher, while the levels of omentin-1 and APN were lower than those in the cerebral infarction group, hypertension group, and healthy control group （all P<0.01）. The levels of blood visfatin and leptin in the cerebral infarction group were higher, while the levels of omentin-1 and APN were lower than those in the hypertension group and the healthy control group （all P<0.01）. The levels of blood visfatin and leptin were higher, while the levels of omentin-1 and APN were lower than those in the healthy control group （all P<0.01）. The levels of blood visfatin and leptin in the vulnerable plaque patients in cerebral infarction complicated with cerebral infarction group and hypertension group were higher, while the levels of omentin-1 and APN were lower than those in stable plaque patients （all P<0.01 ）. Six months after discharge, the levels of blood visfatin and leptin in patients with poor prognosis in cerebral infarction complicated with hypertension group were higher, and the levels of omentin-1 and APN were lower than those in patients with good prognosis （all P<0.01）. Serum omentin-1 and APN were negatively correlated with, while visfatin and leptin were positively correlated with the nature and prognosis of carotid plaque （all P<0.05）. Conclusion The level of serum adipocytokines in patients with cerebral infarction complicated with hypertension is closely related to the nature and prognosis of carotid plaque, which can provide a favorable basis for clinical follow-up diagnosis and treatment.

Key words: Cerebral infarction, Hypertension, Adipocytokines, Carotid plaque, Prognosis