华南预防医学 ›› 2015, Vol. 41 ›› Issue (5): 407-411.doi: 10.13217/j.scjpm.2015.0407

• 论著 • 上一篇    下一篇

1999—2014年六安市艾滋病感染者/患者生存时间及影响因素分析

陈海燕1,2,苏虹1,马功燕2   

  1. 1.安徽医科大学公共卫生学院,安徽 合肥 230032;2.六安市疾病预防控制中心
  • 出版日期:2015-10-20 发布日期:2015-11-06
  • 通讯作者: 苏虹 E-mail:suhong5151@sina.com
  • 作者简介:陈海燕(1985—),女,在读硕士研究生,主管医师,主要从事性病艾滋病预防控制工作

Survival time and related factors among AIDS cases in Lu’an City, 1999-2014

CHEN Haiyan1,2,SU Hong1,MA Gongyan2   

  1. 1.School of Public Health, Anhui Medical University, Hefei 230032,China; 2. Luan Center for Disease Control and Prevention
  • Online:2015-10-20 Published:2015-11-06

摘要: 目的探讨六安市艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者的生存时间及其影响因素。方法收集中国疾病预防控制系统艾滋病综合防治信息系统中1999年至2014年3月六安市报告和管理的全部HIV感染者/AIDS患者的报告卡、附卡、个案随访表、治疗记录及必要的补充调查资料,内容主要包括: 一般人口学特征(性别、年龄、职业、婚姻状况和文化程度)、感染途径、确诊时病期及CD4水平、抗病毒治疗状态和随访结局等。以寿命表法计算生存率,对病例的生存状态进行描述并对影响HIV感染者/AIDS患者的生存状态的相关影响因素进行单、多因素分析。结果共报告661例HIV感染者/AIDS患者,截至调查终点,共有540例HIV感染者/AIDS患者存活并完成随访,存活随访率为81.69%;死亡(死于AIDS及其相关并发症)121例,占18.30%。调查对象中男性512例,女性149例;确诊时年龄最小1岁,最大81岁,中位数为34.5岁。用寿命表法计算确诊HIV感染者/AIDS患者到死亡的生存率情况,1、3和5年生存率分别为83.00%、80.00%和75.00%;HIV感染者/AIDS患者的AIDS相关死亡率为6.70/1 000人月。截止观察终点,12年生存率为67.00%。多因素Cox比例风险模型,结果显示,和确诊时CD4<100个/μL 的HIV感染者/AIDS患者相比,CD4≥100个/μL各组的死亡风险由0.24倍降低至0.03倍;未接受HAART治疗的死亡风险是接受HAART治疗的16.94倍;和60岁及以上组比较,确诊时年龄18岁及以上每减少10岁则死亡风险由0.47倍逐渐降低至0.29倍;女性死亡风险是男性的1.64倍。结论确诊时CD4水平、年龄及性别影响HIV/AIDS的生存时间,HAART治疗是延长HIV/AIDS生存时间的有效手段之一,应进一步扩大HAART 覆盖面。

Abstract: ObjectiveTo analyze the survival time and related factors of HIV/AIDS in Lu’an City.MethodsData of HIV/AIDS report cards, supplementary cards, case followup tables, medical records and necessary supplementary investigation information of Luan City from 1999 to March 2014 were collected from Chinese national HIV/AIDS comprehensive control and prevention information system, including general demographic characteristics (gender, age, occupation, marital status, educational level), route of infection, stage of disease and CD4 levels at confirmed diagnosis, highly active antiretroviral therapy (HAART) and followup outcome. Life table method was applied to calculate the survival rate. The survival status of the patients was described and the related factors affecting survival status of patients with HIV/AIDS were analyzed by univariate and multivariate logistic regressions.ResultsA total of 661 cases of HIV/AIDS were reported. At the end point of the survey, 540 cases of HIV/AIDS survived and finished the followup, with a survival rate of 81.69%; 121 cases died of AIDS and its associated complications with a death rate of 18.30%. Among them, 512 were males and 149, females; their ages ranged from 1 to 81 years old, with a median age of 34.5 years. The survival rate of HIV/AIDS cases at 1, 3, and 5 years were 83.00%, 80.00%, and 75.00%, respectively. The AIDS related mortality was 6.70/1 000 personmonths. At the end point of the investigation, the 12year survival rate of HIV/AIDS was 67.00%. In the Cox proportional hazard model, compared with the cases of HIV/AIDS with CD4 counts fewer than 100 cells/mm3 at diagnosis, the risk of death was decreased from 0.24 to 0.03 time in the cases with CD4 counts equal or greater than 100 cells/mm 3.The risk of death for cases not receiving HAART was 16.94 times that for cases receiving HAART; compared with the cases aged 60 years and older, the risk of death was decreased from 0.47 to 0.29 time for every 10 years of age in the cases aged 18 years and above at confirmed diagnosis. The risk of death for females was 1.64 times that for males.ConclusionCD4 level and age at confirmed diagnosis and gender influenced the survival time of people living with HIV/AIDS. HAART was one of the effective means to prolong the survival time of AIDS patients; therefore, the coverage of HAART should be further expanded.

中图分类号: 

  • R512.91