Abstract: ObjectiveTo analyze the characteristics of occupational exposure to HIV in Zhuhai and explore the preventive measures. MethodsAll the cases of occupational exposure to HIV reported from 2003 to 2014 in Zhuhai City were analyzed using descriptive epidemiological methods. ResultsOne hundred and one cases were reported, including 49 males and 52 females. The male to female sex ratio was 0.94∶1. The median age was 29 years. Of all the cases, 67 cases (66.3%) were health care workers and 26 (25.7%), the police officers; the occupational exposure time occurred mainly from 8∶00 to 11∶59 am and from 14∶00 to 15∶59 (57 cases, 56.4%); the main exposure ways were needle sticking and sharp injuries (61cases, 60.4%); 50.5% of exposures were classified as Level 1; after exposure, 64.4% of cases had correct emergency treatments, 70.3% took medicine for prophylaxis, and no HIV positive cases were found after 6 months. The proportion of the health care workers (68.7%) who received the HIV/AIDS safety operation training was higher than that of the police officers (26.9%) or that of the others (25.0%); the proportion of correct emergency treatment in the exposure regions for the health care workers (73.1%) was also higher than that of the police officers (38.5%) (all P<0.01). ConclusionThe health care workers and police officers are the main occupational groups exposed to HIV in Zhuhai City. The training in occupational exposure protection and the post-exposure emergency treatment, as well as personal protective awareness, should be strengthened.