Abstract: Objective To explore the correlation between self-rated health status and common lifestyle exposure of Tibetans in Lhasa, so as to provide basis for health promotion of Tibetan population. Methods Lhasa Tibetans in National Key R & D Program “Southwest Regional Natural Population Cohort” were selected as the research objects. Face to face electronic questionnaire was used to collect self-rated health status. The environment-wide association study （EWAS） method was used to comprehensively explore the correlation between lifestyle behaviors and self-rated health status. Results Among 6 212 Tibetans, 9.1% of them rated their self-rated health as excellent, 55.9% as good, 28.0% as fair, and 6.9% as poor or very poor. Ordinal Logistic regression analysis in the EWAS framework showed that occasional alcohol consumption （OR=0.79）, regular alcohol consumption （OR=0.66）, dietary score （OR=0.97）, average weekly leisure time exercise duration of 2-3 h （OR=0.72）, and average weekly leisure time exercise duration >3 h（OR=0.84） were more likely to have good self-rated health status. In contrast, people with heavy environmental smoke exposure （OR=1.52） had worse self-rated health status. Conclusion The overall self-rated health status of the Tibetans is optimistic, and a variety of life behavior factors are associated with self-rated health status, providing a theoretical basis for subsequent health education and health promotion.

Key words: Health status, lifestyle, Tibetan, Environment-wide association study, Cohort