Abstract: Objective To investigate the relationship between the polymorphism of the gene of fibroblast growth factor 1（FGF1） and hypertensive intracerebral hemorrhage among Han population in Shanghai. Methods Patients with primary hypertensive intracerebral hemorrhage diagnosed and hospitalized in the department of neurology of a hospital in Shanghai from November 2018 to December 2019 were randomly selected as the intracerebral hemorrhage group. Healthy people of the same gender and similar age who underwent physical examination in the physical examination center of the hospital in the same period were selected as the control group. The data of gender, age, smoking and drinking of the two groups were collected, physical examination and blood pressure measurement were carried out in the two groups. Peripheral venous blood was used to detect blood glucose, blood lipids [triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, apolipoprotein A, apolipoprotein B / lipoprotein （a）] and SNP at rs34018 locus of FGF1. The results were analyzed by descriptive analysis method. Results A total of 58 patients with hypertensive intracerebral hemorrhage were included, with an average age of （70.14±5.08） years, including 36 males and 21 females. In the control group, there were 58 healthy subjects, with an average age of （69.38±6.51） years, including 36 males and 22 females. There was no significant difference in gender, age, blood glucose and blood lipids （triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, apolipoprotein A and apolipoprotein B） between the two groups （all P>0.05）. The diastolic and systolic blood pressures in intracerebral hemorrhage group were higher than those in control group （both P<0.01）. There were significant differences in smoking rate, drinking rate, genotype frequency and allele frequency of SNP at rs34018 locus of FGF1 between the two groups （P<0.05 or P<0.01）. After adjusting for age, gender, blood pressure, lipoprotein （a）, smoking history and drinking history, with genotype AA as a reference, the risk of hypertensive intracerebral hemorrhage in genotype AG increased by 8.242 times （OR=9.242）, and in genotype GG increased by 32.284 times （OR=33.284）. Conclusion Polymorphism of the gene of FGF1 in Han population in Shanghai may promote hypertensive intracerebral hemorrhage, which may be closely related to the GG type at rs34018 locus and the increase of serum lipoprotein （a）.

Key words: Hypertension, Intracerebral hemorrhage, Fibroblast growth factor 1, Single nucleotide polymorphism, Genotype