Abstract: Objective To investigate the effects of thrombin combined with somatostatin on inflammatory factors, coagulation, and fibrinolysis in patients with gastrointestinal bleeding. Methods Patients who received thrombin combined with somatostatin treatment were selected as the observation group, and patients who did not receive thrombin treatment were selected as the control group. The hemostatic effect after treatment, the levels of inflammatory factors, coagulation index and fibrinolysis index before and after treatment, and the occurrence of adverse reactions during treatment were compared between the two groups. Results After treatment, the levels of serum TNF-α, IL-6, CRP, TT, PT, FIB, and D-D in the two groups decreased, and the levels of the above indexes in the observation group were significantly lower than those in the control group （P<0.05 or P<0.01）. The differences of the above indexes before and after treatment in the observation group were greater than those in the control group （all P<0.01）. After treatment, the levels of serum IL-2, APTT, t-PA,APTT and PAI in the two groups increased, and the levels of the above indexes in the observation group were significantly higher than those in the control group （all P<0.01）. The differences of the above indexes before and after treatment in the observation group were lower than those in the control group （P<0.05 or P<0.01）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group （P<0.05）. Conclusion For patients with gastrointestinal bleeding, the combination of thrombin and somatostatin has better efficacy, which can effectively control the level of inflammatory factors, improve coagulation function and vascular fibrinolysis state, and has high safety.

Key words: Thrombin, Somatostatin, Gastrointestinal bleeding, Inflammatory factor, Coagulation, Fibrinolysis