Abstract: Objective To investigate the 10-year risk of ischemic cardiovascular disease (ICVD) and its associated factors among individuals aged 35 years and older in Huai'an City. Methods A multi-stage cluster random sampling method was employed to select participants aged ≥35 years in Huai'an. The "10-Year ICVD Risk Assessment Chart for Chinese Populations" was utilized to evaluate the 10-year ICVD incidence risk for each participant. Multinomial logistic regression analysis was conducted to identify the factors influencing this risk. Results A total of 10 744 individuals were included in the study, comprising 5 980 males and 4 764 females, with a mean age of 64.68±10.31 years. The average 10-year ICVD risk score was 8.63±3.48. The mean score for males was significantly higher than for females (9.26±3.45 vs. 7.84±3.36; P<0.01). The proportions of the population at low, medium, and high risk were 60.23%, 20.30%, and 19.47%, respectively. With the low-risk group as the reference, multinomial logistic regression analysis revealed that alcohol consumption (Medium-risk group: OR=1.158; High-risk group: OR=1.240), being a farmer (Medium-risk group: OR=1.206; High-risk group: OR=1.120), education level of primary school or below (Medium-risk group: OR=2.438; High-risk group: OR=3.380), abnormal triglyceride (TG) levels (Medium-risk group: OR=1.241; High-risk group: OR=1.288), and abnormal low-density lipoprotein cholesterol (LDL-C) levels (Medium-risk group: OR=1.681; High-risk group: OR=2.428) were associated with a higher likelihood of being in the medium- and high-risk categories for 10-year ICVD incidence. A junior high school education was associated with a greater risk of being in the high-risk category (OR=1.542). Conversely, being male (Medium-risk group: OR=0.827; High-risk group: OR=0.692), residing in an urban area (Medium-risk group: OR=0.795; High-risk group: OR=0.725), and having abnormal high-density lipoprotein cholesterol (HDL-C) levels (Medium-risk group: OR=0.754; High-risk group: OR=0.722) were associated with a lower risk of being in the medium- and high-risk groups (all P<0.05). Conclusion The 10-year risk of ICVD is relatively high among the population aged ≥35 years in Huai'an. Particular attention should be directed towards females, farmers, rural residents, individuals who consume alcohol, and those with abnormal TG and LDL-C levels.

Key words: Ischemic cardiovascular disease, Risk assessment, Risk factors