Abstract: Objective To investigate the prevalence of depression and its related factors in women with perimenopausal syndrome in the mountainous area of Xingtai.MethodsA stratified cluster sampling method was used to select female residents meeting standards from 935 administrative villages of 4 counties or city (counties of Xingtai, Lincheng, and Neiqiu, and Shahe City) in the mountainous area of Xingtai. A questionnaire survey was conducted with self-designed questionnaire. Investigation content included the basicinformation of the subjects, Kupperman score and 17-item Hamilton Rating Scale for Depression (HAMD-17). The prevalence of depression among the participants with perimenopausal syndrome were analyzed and described. Univariate and multivariate logistic regressions were used to analyze factors influencing depression in the subjects with perimenopausal syndrome.ResultsA total of 1 668 participants were investigated and their average age was (51.26 ± 7.38) years. They were mainly 40-49 years old, accounting for 55.34% of the total subjects (923/1 668). The prevalence of depression in the subjects was 50.07% (348/695). The severity of perimenopausal syndrome was positively correlated with the severity of depression (P<0.01). Multivariate logistic regression showed that the subjects who had no spouse（OR=3.865）, chronic disease（OR=5.114）, poor family relationship (OR=6.197）, and poor neighbor relationship（OR=2.366）were more likely to have higher incidence of depression. ConclusionThe prevalence of depression in women with perimenopausal syndrome was high in the mountainous area of Xingtai. Measures of treating chronic diseases of the high-risk group and harmonizing the relationship with their family and neighbors should be taken to prevent perimenopausal depression.