澄迈地区中老年女性25-羟维生素D水平及维生素D受体基因多态性与骨密度关联性分析

doi:10.12183/j.scjpm.2023.0709

Abstract

Abstract: Objective To investigate the association between serum 25-hydroxyvitamin D level or vitamin D receptor （VDR） gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region. Methods Middle-aged and elderly women ≥45 years old who underwent physical examination in Chengmai County People's Hospital, Chengmai County Traditional Chinese Medicine Hospital, and Yongfa Health Center in Chengmai County from December 2019 to December 2022 were selected for this study. Baseline data of the study subjects were collected, and serum 25-hydroxyvitamin D level, VDR gene polymorphism, and bone mineral density were detected. The association between VDR gene polymorphism or 25-hydroxyvitamin D level and bone mineral density was analyzed. Results A total of 3 016 middle-aged and elderly women were included, aged 45-77 years, with an average age of （60.98±8.46） years. There were 1 900 cases with abnormal bone mineral density, accounting for 63.00%. There were significant differences in bone mineral density among different age, BMI, hypertension, menopause, and 25-hydroxyvitamin D level （all P<0.01）. VDR gene polymorphism detection results showed that there were polymorphisms at ApaI, FokI, and TaqI loci of VDR genes in middle-aged and elderly women in Chengmai region, and the genotypes of ApaI, FokI, and TaqI loci were AA/Aa/aa, FF/Ff/ff, TT/Tt/tt, respectively. Logistic regression analysis showed that aged 65 and over （OR=3.931）, BMI overweight/obesity （OR=2.171）, combined hypertension （OR=1.634）, menopause （OR=2.413）, 25-hydroxyvitamin D deficiency （OR=3.086）, VDR ApaI genotype AA （OR=2.307）, FokI genotype ff （OR=2.494）, and TaqI genotype TT （OR=2.784） were associated with abnormal bone mineral density in middle-aged and elderly women. Conclusion The incidence of abnormal bone mineral density is high in middle-aged and elderly women in Chengmai region, and the 25-hydroxyvitamin D level and VDR gene polymorphism are closely related to bone mineral density.

Key words: Middle-aged and elderly, Woman, 25-hydroxyvitamin D, Vitamin D receptor gene polymorphism, Bone mineral density

CLC Number:

R173

LIANG Dingchuan, ZHANG Pijun, WANG Wei, LIU Qiang, LIANG Zunsen. Association analysis of 25-hydroxyvitamin D level or vitamin D receptor gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region[J].South China Journal of Preventive Medicine, 2023, 49(6): 709-713.

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Association analysis of 25-hydroxyvitamin D level or vitamin D receptor gene polymorphism and bone mineral density in middle-aged and elderly women in Chengmai region

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