Abstract: ObjectiveTo analyze the space-time interaction and characteristics of hand, foot, and mouth disease (HFMD) in fine scale, so as to provide a basis for precise prevention and control. MethodsThe case data of HFMD in Yuexiu District, Guangzhou City in 2014 were obtained from China Information System for Disease Control and Prevention, and the social and demographic data were collected from Statistical Yearbook. Descriptive statistics were performed to describe the distribution of the disease and the Knox test was applied to analyze the space-time interaction.ResultsA total of 3 265 cases of HFMD were reported in Yuexiu District in 2014. There were space-time interactions and the strongest spatial and temporal clustering occurred in 4 days and 200 meters. The strength of spatiotemporal clustering in females was stronger than that in males. The 0-2 years age group was clustered in the 1st, 4th-7th days, 3-6 years age group was clustered in the 1st, 4th-5th, 9th-11th days, and the age group 7 years and over was clustered in 2nd, 7th-8th days. The strengths of clustering were strong within 400 meters for scattered children and in the range of 300-900 meters for the students. The relative-risk of HFMD showed an increasing trend within 4 days and 200 meters.ConclusionHFMD is more likely to occur within short time and short distance. Females, children aged 3-6 years, and children in kindergartens are high risk group for HFMD clustering. Prevention and control measures can be taken according to the spatio temporal characteristics to reduce HFMD clustering.