Abstract: Objective To describe the impact of epidemiological trend of disease mortality on life expectancy and potential years of life loss （PYLL） among registered residents in Guangzhou from 2010 to 2016. Methods Surveillance data of causes of death of registered residents in Guangzhou from 2010 to 2016 were obtained from the Cause of Death Registration Information System. The classification of causes of death was coded and analyzed based on ICD-10. The mortality rate, life expectancy, and PYLL were analyzed and the impact of disease death on life expectancy and PYLL was described. Results The total deaths of registered residents were 327 769 in Guangzhou from 2010 to 2016, with a mean mortality rate of 563.67/100 000 （standardized rate, 327.19/100 000）, rising slowly at an annual average rate of 0.66%. The top three causes of death were cardiovascular and cerebrovascular diseases （204.61/100 000）, malignant tumors （148.43/100,000） and respiratory diseases （88.99/100,000）.The mortality rates of injury and poisoning, musculoskeletal and connective tissue diseases, and endocrine, nutritional and metabolic diseases increased by 11.54%, 10.62%, and 5.53% annually on average,respectively. The annual average PYLL was 443 653 person-years, with a PYLL rate of 53.20‰, showing an upward trend. The top three causes of death resulting in PYLL were malignant tumors, cardiovascular and cerebrovascular diseases, and injury and poisoning, with average PYLL of 177 631, 88 302 and 58 678 person-years, respectively. Conclusion The leading causes of death influencing the life expectancy were cardiovascular and cerebrovascular diseases, malignant tumors, and respiratory diseases among registered residents in Guangzhou from 2010 to 2016. The top three causes of death resulting in PYLL were malignant tumors, cardiovascular and cerebrovascular diseases, and injury and poisoning.

Key words: Mortality rate, Cause of death, Life table, Residents