Abstract: Objective To explore the intention of quitting smoking and its influencing factors among workers of enterprises so as to provide scientific evidence for developing effective tobacco control measures. Methods Smoking workers were selected by convenient sampling method from ten enterprises in Sanxiang Town of Zhongshan City. They were asked to complete a structured questionnaire on socio-demographic characteristics, smoking-related knowledge and attitudes, smoking behaviors, past quitting experiences and quitting intentions. Univariate and multiple logistic regressions were employed to test associations between intention to quit smoking and independent variables of interest. Results A total of 1 573 smokers were surveyed (1 353 males and 174 females). Of them, 664 (42.2%) had tried to quit smoking and 676 (43.0%) intended to quit smoking. The average scores of smoking-related knowledge and attitudes were (11.5±3.9) and (77.0±9.9) points, respectively, and the average score of nicotine dependence was (3.5±2.5) points. Multiple logistic regression indicated that those with the experience of ever quitting (OR =2.56), confidence of quitting smoking (OR =14.47), higher scores of smoking-related knowledge (OR =1.05) and attitudes (OR =1.05) inclined to have greater intentions to giving up smoking; compared with people with monthly income of 2 000 Yuan or less, those with monthly income more than 4 000 Yuan were less likely to stop smoking（OR =0.48）. Conclusion The score of smoking-related knowledge was low among the workers in enterprises. For tobacco control in enterprises， health education, including correct Methods of quitting smoking, should be strengthened for tobacco control in enterprises.