Abstract: Objective To analyze the correlation of obesity and physical activity with serum liver function indicators in the middle-aged and elderly population in Guangzhou. Methods Based on the data of Guangzhou Biobank Cohort Study,multiple linear regression model was used to analyze the correlation of central obesity,systemic obesity,and physical activity with various serum liver function indicators. The effects of the interaction between obesity and physical activity on liver function indicators were evaluated by adding interaction terms. Results A total of 8 714 participants with a mean age of （64.65±6.05）years were included. There were 6 251 females （71.74%）and 2 463 males （28.26%）. Compared with the non-central obesity group,the central obesity group had higher alanine aminotransferase （ALT）and aspartate aminotransferase （AST）levels,and lower albumin （ALB）levels,and the regression coefficients β were 4.74,0.66,and -0.27 IU/L,respectively （all P < 0.01）. Compared with the non-systemic obesity group,the systemic obesity group had higher ALT and AST levels and lower ALB levels,and the regression coefficients β were 5.72,1.23,and -0.36 IU/L,respectively （all P < 0.01）. AST levels in inactive group were higher than those in active group,and the regression coefficient β was 0.53 IU/L （P < 0.01）. Conclusion Central obesity,systemic obesity,and low physical activity level were significantly correlated with abnormal serum liver function indicators,suggesting the importance of obesity management and increasing physical activity in maintaining liver function.

Key words: Obesity, Physical activity, Liver function indicator