Abstract: Objective To observe the effect of life behavior intervention on metabolic function in obese patients with type 2 diabetes mellitus （T2DM）. Methods Obese patients with T2DM in Longhua District, Haikou City, from January 2020 to June 2022 were selected and divided into intervention group and control group according to random number table. The control group received conventional drug therapy, basic diet and exercise therapy, and the intervention group added intensive life behavior intervention for 6 months on the basis of conventional treatment. The changes of obesity indicators, blood glucose indicators, blood lipid indicators, islet function indicators, and quality of life of the two groups were compared before and after intervention. Results Among the obese patients with T2DM included in this study, there were 1 487 effective cases in the control group and 1 481 effective cases in the intervention group. There was no significant difference in age, gender, educational background, and course of disease between the two groups（all P>0.05）. After 3 and 6 months of treatment, waist circumference, body mass index （BMI）, fasting blood glucose （FBG）, 2 hours postprandial blood glucose （2hPG）, glycosylated hemoglobin （HbA1c）, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL‐C）, fasting insulin （FINS）, and homeostatic model assessment for insulin resistance （HOMA‐IR） in the intervention group were lower than those in the control group, while high density lipoprotein cholesterol （HDL‐C） and homeostatic model assessment- β （HOMA-β） were higher than those in the control group （P<0.05 or P<0.01）. The diabetes quality of life （DQOL） score of the intervention group was lower than that of the control group （P<0.05）. Conclusion Life behavior intervention can reduce BMI in obese patients with T2DM, regulate blood lipid metabolism, improve islet function, and improve their quality of life.

Key words: Obesity, Type 2 diabetes melllitus, Life behavior intervention, Metabolic function