Abstract: Objective To analyze the status quo and influencing factors of the quality of life （QOL） of residents living in urban-rural integration so as to provide reference for health education and improve their QOL. Methods Residents living in urban-rural continuum in Panyu District, Guangzhou were selected by the multi-stage sampling method in 2018. The social demographic data and the SF-36 scale evaluation score were collected by questionnaire. The results are described using a descriptive epidemiological analysis method. Results A total of 510 valid questionnaires were collected, with an effective rate of 94.45%. Of the respondents, 96.5% （492/510） were permanent residents with local household registration and 63.3% （323/510） were female. 36.0%, 26.6%, and 37.4% of the participants were aged 16-44, 45-59 and ≥60 years, respectively; 42.2% had the education levels at college/undergraduate or above. The general health （GH） score was （70 ± 15）. The scores of physiological functioning （PF）, role-physical（RP）, bodily pain （BP）, and vitality （VT） were （90 ± 15）, （87 ± 28）, （90 ± 16）, and （81±16）; the scores of social functioning （SF）, role-emotional （RE）, and mental health （MH） were （85 ± 20）, （90 ± 26）, and （81 ± 16）, respectively. Multivariate analysis showed that female residents had a lower probability of having higher PF scores than men （OR=0.46）; the younger the age, the higher the RP scores （OR=2.39, 4.09）; compared with employees in enterprises, employees in public institutions had higher PF and RE scores （OR=2.60, 2.66）.Residents without chronic diseases scored higher on PF than those with chronic diseases （OR=2.34）. Compared with junior college/undergraduand and above, the residents with educational levels in junior high school and below had lower scores of RP （OR=0.30,0.40）, the residents with high school or below had lower scores of RP （OR=0.29, 0.23,0.27）, and the residents with educational levels at junior high school had lower scores of GH （OR=0.34）.Compared with residents with chronic diseases, the residents without chronic diseases scored higher in BP and GH （OR=1.58,2.50）.Compared with employees in enterprises, farmers and workers had lower MH scores （OR=0.49,0.55）.Conclusion The QOL of residents in urban-rural continuum in Panyu District, Guangzhou City was low. The QOL of male residents, and residents with higher education levels and jobs in public institutions was higher. The older age, working in enterprises and chronic diseases had adverse effects on QOL.

Key words: Quality of life, Questionnaire survey, Urban-rural continuum, Resident