Abstract: Objective To analyze the epidemiological characteristics of COVID-19 of Guangzhou Baiyun International Airport and evaluate the epidemic prevention and control effect， so as to provide theoretical basis for further development of COVID-19 overseas entry prevention and control in Guangzhou Baiyun International Airport. Methods The data of COVID-19 published in Guangzhou City from March 15 to April 15， 2020 were collected， and the epidemic characteristics were analyzed by descriptive epidemiology method.Combined with a series of measures for epidemic prevention and control， the intervention effect was evaluated. Results By 24∶00 on April 15， 2020， a total of 142 cases had entered Guangzhou Baiyun International Airport， including 120 confirmed cases， 3 asymptomatic cases and 19 imported related cases. There were 122 cases （85.92%） aged 20-60 years old， 86 cases （60.56%） were male and 56 cases （39.44%） were female； 112 cases （78.87%）were Chinese nationality and 30 cases（21.13%） were foreign nationality； there were 70 cases （49.30%） from Euro?American countries； 46 cases （32.39%） were international students and 62 cases （43.66%） were in?service staff； 77 cases （54.23%） were screened at frontier ports. The epidemic curve peaked on March 21， and then fell down slowly. After the implementation of a series of prevention and control measures， all inbound flights were fully inspected， and there was no case of infection and death of quarantine personnel. Conclusion With the continuous aggravation of overseas epidemic situation， new situation of imported epidemic situation in Guangzhou has emerged. It is suggested that based on the preliminary prevention and control measures and deployment requirements， the prevention and control strategies and measures should be further consolidated in view of the new situation of epidemic prevention.

Key words: COVID-19, Epidemiological characteristic, Prevention and control effect