Abstract: Objective To investigate the depression and anxiety status of chronic hepatitis C patients and its influencing factors. Methods A total of 480 patients with chronic hepatitis C reported by Kunming infectious disease surveillance system from January 2013 to December 2018 were randomly selected as the research objects, Self Rating Anxiety Scale （SAS） and Self Rating Depression Scale （SDS） were used to evaluate the degree of depression and anxiety in patients with chronic hepatitis C. Single factor analysis and Logistic regression analysis were used to screen the related factors of depression and anxiety. Results In 480 patients with chronic hepatitis C, 320/160 were male/female, the average age was （45.40 ± 3.72） years, and the course of disease was 0.5-12.0 years, with an average of （7.63 ± 2.45） years. The patients' SDS score was （47.81±9.69） and SAS score was （42.62±9.53）, among which 124 cases （25.83%） with SDS≥53 and 110 cases （22.92%） with SAS≥50. Logistic regression analysis showed that junior high school or below （OR=2.986）, intermediate personality （OR=1.895）, introverted personality （OR=1.869）, per capita monthly income < 1 000 yuan （OR=3.735）, and feeling discriminated against （OR=1.447） were independent risk factors of depression in patients with chronic hepatitis C, while knowledge of preventive measures （OR=0.326） were protective factors. Intermediate personality （OR=1.957）, introverted personality （OR=2.043） and feeling discriminated against （OR=1.862） were the risk factors affecting anxiety, and knowledge of preventive measures （OR=0.387） was the protective factor. Conclusion The depression and anxiety scores of patients with chronic hepatitis C in Kunming are at a high level. The risk factors of depression and anxiety are low education level, introverted personality, low income and feeling discriminated against, while knowing preventive measures is a protective factor.

Key words: Chronic hepatitis C, Depression, Anxiety, Influencing factor