Abstract: Objective To investigate the non-suicidal self-injury （NSSI） of adolescents with depression in Shanghai and analyzed its influencing factors. Methods Adolescent patients with depression admitted to Shanghai Mental Health Center from January to December 2022 were selected to diagnose the occurrence of NSSI, and the demographic information, environmental information, degree of depression, childhood family dysfunction, and other information of the patients were investigated. Univariate and multivariate methods were used to analyze the influencing factors of NSSI. Results Among the 795 adolescents with depression, 275 were males, with a mean age of （14.97±1.72） years, and 287 （36.10%） had NSSI. The results of multivariate logistic regression analysis showed that experienced school violence （OR=1.874）, childhood family dysfunction （OR=3.740）, witnessed domestic violence （OR=5.618）, lived with a family member with alcohol or substance abuse （OR=4.702）, had impulsivity （OR=2.575）, had negative impulse events （OR=6.080）, had childhood trauma injury （OR=8.482）, and emotional abuse （OR=7.272） were all associated with NSSI in adolescents with depression. Conclusion The occurrence of NSSI in adolescents with depression in Shanghai is related to personal experience, family environment, and social relations, so psychological treatment and intervention measures should be taken accordingly.

Key words: Adolescent, Depression, Non-suicidal self-injury, Influencing factor