South China Journal of Preventive Medicine ›› 2021, Vol. 47 ›› Issue (9): 1135-1138.doi: 10.12183/j.scjpm.2021.1135

• Original Article • Previous Articles     Next Articles

Risk factors of multidrug-resistant organisms infection in patients with diabetic foot

YUAN Hong-yan1, YU Nan2, WANG Yuan-yuan1   

  1. 1. Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao 266000, China;
    2. Qingdao Central Hospital
  • Received:2021-02-19 Published:2021-10-18

Abstract: Objective To investigate the risk factors and pathogenic bacteria distribution of patients with diabetic foot who developed multidrug-resistant organisms (MDROs) infection. Methods From January 2019 to December 2020, patients with diabetic foot in endocrinology clinic of a tertiary hospital in Qingdao were selected as the research subjects for data collection, physical examination and fasting venous blood collection, and the cotton swab was used to wipe the wound and wipe out the secretions for pathogen infection and drug resistance detection. Descriptive epidemiological analysis method was used for analysis, and univariate and multivariate analysis methods were used to analyze the influencing factors of multi-drug resistance. Results A total of 5 122 patients with diabetic foot were analyzed for MDROs infection. The patients were 35 to 85 years old, with an average of (61.03±11.19) years old, and the course of diabetes was 1 to 29 years, with an average of (12.32±7.16) years. There were 210 cases of multiple infections, and the multiple infection rate was 4.10%. A total of 265 MDROs were isolated, and the top 3 MDROs were 109 strains of Staphylococcus aureus (41.13%), 61 strains of Pseudomonas aeruginosa (23.02%), and 58 strains of Escherichia coli (21.89%). Among the main MDROs, Staphylococcus aureus was 100% resistant to oxacillin, ampicillin/sulbactam, and cefazolin, and Escherichia coli was 100% resistant to ampicillin, piperacillin/tazobactam, and ceftazidime. No bacteria resistant to vancomycin. The results of multivariate Logistic regression analysis showed that the history of antimicrobial exposure (OR=1.962), the number of hospitalizations for the same wound>2 times/year (OR=1.970), osteomyelitis (OR=4.323), neuro ischemic wounds (OR=1.269) and antimicrobial treatment course ≥5 d (OR=1.487, 3.274, 1.602) were risk factors for MDROs infection. Conclusion A history of antimicrobial exposure, hospitalization > 2 times/year for the same wound, osteomyelitis, neuro ischemic wounds, and the use of antimicrobial courses in diabetic foot patients are strongly associated with MDROs infection.

Key words: Diabetic foot, Multidrug-resistant organisms, MDROs infection, Risk factor

CLC Number: 

  • R195