Abstract: Objective To study the situation and influencing factors of catheter-related infection in patients with blood purification, so as to provide reference for the prevention and reduction of catheter-related infection in patients with blood purification. Methods A total of 1 781 patients receiving blood purification in the Department of Nephrology, West China Hospital, Sichuan University from January 2018 to June 2021 were selected as the research objects, the occurrence of catheter-related infection in patients was observed, univariate and multivariate analysis methods were performed on the factors that may lead to infection. Results Among 1 781 patients with blood purification, 942 were male and 839 were female. The age ranged from 37 to 76 years, with average of （65.9 ± 5.6） years. Catheter-related infection occurred in 317 cases, and the incidence rate was 17.80%. The constituent ratio of infection causes from high to low was tunnel infection （95 cases, 29.97%）, catheter colonization （89 cases, 28.08%）, export infection （70 cases, 22.08%）, and bloodstream infection （63 cases, 19.87%）. There were statistically significant differences in the incidence of catheter-related infection among patients with different ages, whether with diabetes mellitus, whether with hypoproteinemia, puncture times, indwelling catheter time, hospitalization time and application of antibiotics （all P<0.01）. Multivariate Logistic regression analysis showed that age （OR=1.706）, diabetes mellitus （OR=2.077）, hypoproteinemia （OR=1.960）, puncture times ≥2 （OR=1.283）, indwelling catheter time ≥ 1 week （OR=2.588）, hospitalization time≥ 2 weeks （OR=1.387） and application of antibiotics （OR=0.352） were the influencing factors of catheter-related infection in patients with blood purification. Conclusion The rate of catheter-related infection in patients with blood purification is high, which is related to age, diabetes mellitus, hypoproteinemia, puncture times, indwelling catheter time, hospitalization time and application of antibiotics.

Key words: Blood purification, Catheter-related infection, Influencing factor