某儿童成长配方奶粉对微量营养素不足饲料喂养大鼠生长发育、骨量及钙吸收的影响

doi:10.12183/j.scjpm.2022.0792

Abstract

Abstract: Objective To investigate the effects of nutrition enhancement or supplement with a growth formula milk powder for children （hereinafter referred to as formula） on growth and bone density of rats. Methods Sixty two weaned SD rats, half male and half female, were randomly assigned to three groups, which were fed with malnutrition diet, nutrition-enhanced diet, and nutrition-supplemented diet, respectively. The body length and weight of the rats were monitored. After 8 weeks of feeding, the calcium absorption test was carried out. After 12 weeks of feeding, bone mineral density （BMD） and bone mineral content （BMC） of the whole-body, spine bone, and limb bones were measured. Results Compared with the malnutrition group, the final body weight, BMD of whole body, spine, and limbs, BMC of whole body and limbs were significantly increased in female rats of the nutrition-enhanced group and the nutrition-supplemented group （all P<0.05）, the final body length were increased in female rats of the nutrition-supplemented group （P<0.05）. Compared with the malnutrition group, the final body weight and body length were increased in male rats of the nutrition-supplemented group （all P<0.05）, while BMD of whole body, spine and limbs, BMC of whole body and limbs were increased in male rats of the nutrition-enhanced group and the nutrition-supplemented group （all P<0.05）. Compared with the malnutrition group, BMC of spine was increased in male rats of the nutrition-supplemented group （P<0.05）. Compared with the malnutrition group, the calcium absorption rate was increased in both male and female rats of the nutrition-enhanced group and the nutrition-supplemented group （all P<0.05）. Compared with the nutrition-enhanced group, the body weight and body length of male rats in the nutrition-supplemented group increased faster, and the BMC of whole body, BMD and BMC of limbs increased （all P<0.05）. Conclusion The body length, body weight, BMD, BMC, and calcium absorption rate of rats fed with micronutrient deficient diet were improved by supplementation of formula with AIN-93G or malnutrition diet. Moreover, in male rats, adding formula to micronutrient deficient diet could catch up with the fortified diet in weight gain, BMD, and BMC.

Key words: Malnutrition, Bone mass, Calcium absorption, Growth and development

CLC Number:

R151.3

HUANG Si-yu, CHEN Si, HE Tong-tong, YE Xing-wang, FANG Hong-tao, LIU Zheng-dong, YAN Zhi-yuan, ZHU Hui-lian. Effects of a growth formula milk powder for children on growth, bone mass, and calcium absorption of rats fed micronutrient deficient diet[J].South China Journal of Preventive Medicine, 2022, 48(7): 792-796.

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Effects of a growth formula milk powder for children on growth, bone mass, and calcium absorption of rats fed micronutrient deficient diet

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