广州市大学生邻苯二甲酸二（2-乙基己基）酯暴露与生活方式相关性分析

doi:10.12183/j.scjpm.2020.0622

摘要/Abstract

摘要： 目的探讨广州市大学生体内邻苯二甲酸二（2-乙基己基）酯（DEHP）的暴露水平及与生活方式的相关性。方法采用方便抽样法在广州市中山大学东校园和北校园内招募大学生,收集每名大学生晨尿并进行问卷调查,问卷内容包括一般情况、饮食习惯及个人护理产品的使用情况等。采用气相色谱-质谱联用法测定尿样中DEHP的一级代谢产物邻苯二甲酸单（2-乙基己基）酯（MEHP）浓度。采用单、多因素Logistic回归分析方法对生活方式与尿中MEHP浓度的关系进行分析。结果回收并匹配尿样的有效调查人数共123人。男性占44.7%,医学相关专业占61.0%。尿样中MEHP检出率为90.2%,检测值中位数为0.49 μg/mL。多因素Logistic回归分析结果显示,使用外卖餐盒≥1次/周（OR=2.910）的在校大学生晨尿中MEHP浓度高的可能性更大。使用沐浴露≥7次/周（OR=0.445）、接触毛绒玩具（OR=0.282）的在校大学生晨尿中MEHP浓度高的可能性更小。结论广州市大学生尿中MEHP检出率高,提示该人群DEHP暴露风险高,与个人生活方式以及相关塑料制品的使用有关。应倡导大学生形成健康生活方式,尽量避免DEHP暴露。

关键词: 大学生, 尿液, 邻苯二甲酸酯, 生活方式

Abstract: Objective To assess the exposure levels of di-（2-ethylhexyl）phthalate （DEHP） and its correlation with lifestyle in college students in Guangzhou.Methods A convenient sampling method was used to recruit college students from East and North campuses of Sun Yat-sen University in Guangzhou. The participant was asked to provide a morning urine sample and complete a questionnaire on general demographic information, dietary habits and use of personal care products. The concentration of mono （2-ethylhexyl） phthalate （MEHP）, a primary metabolite of DEHP in urine samples was determined by gas chromatography-mass spectrometry. The correlation between MEHP concentration levels and influencing factors were analyzed by using univariate and multivariate logistic regressions.Results A total of 123 valid questionnaires matched with urine samples were collected. Of the participants, 44.7% were male and 61.0% were majored in medicine-related specialties. The detection rate of MEHP in urine samples was 90.2%, with a median of 0.49 μg/ml. In the multivariate logistic regression model, the college students who used take-out lunch boxes more than once a week （OR = 2.910） were more likely to have higher MEHP concentrations in the morning urine, while those who used shower gel ≥7 times a week （OR = 0.445） or touched plush toys （OR = 0.282） were less likely to have higher MEHP concentrations in the morning urine.Conclusion The detection rate of MEHP in urine of college students in Guangzhou was high, indicating that the risk of DEHP exposure in this population was higher, and related to personal lifestyle and the use of related plastic products. College students should be encouraged to form a healthy lifestyle, and try to reducing the level of DEHP exposure in the body.

Key words: College students, Urine, Phthalate metabolite, Lifestyle

中图分类号:

R155.5+1

杨国怡, 何婧楠, 高梦琦, 孙悦, 卢映洁, 王畅, 冯丹. 广州市大学生邻苯二甲酸二（2-乙基己基）酯暴露与生活方式相关性分析[J]. 华南预防医学, 2020, 46(6): 622-625.

YANG Guo-yi, HE Jing-nan, GAO Meng-qi, SUN Yue, LU Ying-jie, WANG Chang, FENG Dan. Correlation between di-（2-ethylhexyl）phthalate exposure levels and lifestyles of college students in Guangzhou[J]. South China Journal of Preventive Medicine, 2020, 46(6): 622-625.

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