关键词: 肺腺癌, 表皮生长因子受体, 基因突变

Abstract: Objective To investigate the mutation of EGFR gene in patients with lung adenocarcinoma and its correlation with clinical, imaging, and pathological features. Methods A total of 370 patients with lung adenocarcinoma who were diagnosed and treated in a cancer hospital in Hainan Province from August 2017 to July 2021 were selected as the research subjects. According to the results of EGFR gene detection, they were divided into wild-type group and mutation group. The data of sex, age, stage, type of adenocarcinoma, IASLC grade, histological subtype, and CT inmaging characteristics of the two groups were analyzed by univariate and multivariate regression analysis. Results After EGFR gene detection, there were 172 patients with EGRF gene mutation and 198 patients with EGFR wild type, the gene mutation rate was 46.49%; 75 patients had EGFR gene exon 19 mutation, accounting for 43.60% of the mutation group; 97 patients had EGFR gene exon 21 mutation, accounting for 59.40% of the mutation group. Multivariate Logistic regression analysis showed that female, smoking history, burr sign, air bronchus sign, and papillary invasive mucinous adenocarcinoma were risk factors for EGFR mutation （all P<0.05）; Minimally invasive adenocarcinoma was a protective factor for EGFR mutation （P<0.05）. There was no significant difference in clinical data, imaging, and pathological features between patients with EGFR gene exon 19 and exon 21 mutations （all P>0.05）. Conclusion EGFR gene mutation in patients with lung adenocarcinoma has related imaging and pathological features, which has reference value for formulating personalized treatment plan for patients.

Key words: Lung adenocarcinoma, Epidermal growth factor receptor, Gene mutation