华南预防医学 ›› 2026, Vol. 52 ›› Issue (1): 18-24.doi: 10.12183/j.scjpm.2026.0018

• 论著 • 上一篇    下一篇

潮州市潮安区居民BMI、腰围与血脂异常患病的剂量-反应关系

蒋蓉1, 陈思彤1, 吴玉霞1, 刘裕国1, 蔡卫斌2, 李少琳2, 叶小华1   

  1. 1.广东药科大学公共卫生学院,广东 广州 510310;
    2.潮州市潮安区疾病预防控制中心
  • 收稿日期:2025-03-09 出版日期:2026-01-20 发布日期:2026-02-06
  • 通讯作者: 叶小华,E-mail:smalltomato@163.com
  • 作者简介:蒋蓉(1999—),女,在读硕士研究生,研究方向:疾病预防与控制
  • 基金资助:
    广东省研究生教育创新计划项目(2020JGXM066); 潮州市潮安区疾病预防控制中心课题(HTDJ2024-059)

Dose-response relationship between body mass index, waist circumference, and the prevalence of dyslipidemia among residents of Chao'an District, Chaozhou

Jiang Rong1, Chen Sitong1, Wu Yuxia1, Liu Yuguo1, Cai Weibin2, Li Shaolin2, Ye Xiaohua1   

  1. 1. School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China;
    2. Chao'an District Center for Disease Control and Prevention, Chaozhou
  • Received:2025-03-09 Online:2026-01-20 Published:2026-02-06

摘要: 目的 分析潮州市潮安区居民BMI、腰围与血脂异常患病的剂量-反应关系,为血脂异常的综合防控提供科学依据。方法 2024年5—6月采用多阶段整群随机抽样方法对潮州市潮安区≥18岁居民进行问卷调查、体格测量和实验室检查。采用非条件logistic回归模型分析BMI、腰围与血脂异常的关系,采用基于限制性立方样条的logistic模型分析BMI、腰围与血脂异常患病的剂量-反应关系。结果 潮州市潮安区居民血脂异常患病率为34.00%,超重/肥胖率为30.74%,中心肥胖率为23.86%。超重/肥胖居民(OR=2.18,95% CI:1.87~2.55)和中心肥胖居民(OR=2.13,95% CI:1.81~2.52)血脂异常患病危险度均高于体重正常居民。以正常体重者为参考,超重/肥胖+中心性肥胖者患血脂异常的危险度(OR=2.76,95 CI%:2.27~3.36)高于仅超重/肥胖者(OR=1.85,95% CI:1.49~2.29)、仅中心性肥胖者(OR=1.70,95% CI:1.28~2.28)。限制性立方样条模型显示,BMI和腰围与血脂异常患病均存在非线性剂量-反应关系(均P<0.05)。结论 潮州市潮安区居民BMI、腰围与血脂异常患病有关,且存在明显的单调递增剂量-反应关系。

关键词: 肥胖, 血脂异常, 剂量-反应关系, 限制性立方样条

Abstract: Objective To analyze the dose-response relationship between Body Mass Index (BMI), waist circumference, and the prevalence of dyslipidemia, in order to provide a scientific basis for the comprehensive prevention and control of dyslipidemia. Methods From May to June 2024, a multi-stage cluster random sampling method was employed to conduct a questionnaire survey, physical examinations, and laboratory tests on residents aged 18 and older in the Chao'an District. An unconditional logistic regression model was used to analyze the association between BMI, waist circumference, and dyslipidemia. A logistic regression model based on restricted cubic splines (RCS) was utilized to analyze the dose-response relationship between BMI, waist circumference, and the prevalence of dyslipidemia. Results The prevalence of dyslipidemia among residents of Chao'an District was 34.00%, with an overweight/obesity rate of 30.74% and a central obesity rate of 23.86%. The risk of dyslipidemia was higher in residents with overweight/obesity (OR=2.18, 95% CI: 1.87-2.55) and central obesity (OR=2.13, 95% CI: 1.81-2.52) compared to residents with normal weight. Referencing the normal weight population, individuals with combined overweight/obesity and central obesity had a higher risk of developing dyslipidemia (OR=2.76, 95% CI: 2.27-3.36) than those with only overweight/obesity (OR=1.85, 95% CI: 1.49-2.29) or only central obesity (OR=1.70, 95% CI: 1.28-2.28). The restricted cubic spline model indicated a non-linear dose-response relationship between both BMI and waist circumference and the prevalence of dyslipidemia (both P<0.05). Conclusion BMI and waist circumference are associated with the prevalence of dyslipidemia, exhibiting a clear, monotonically increasing dose-response relationship.

Key words: Obesity, Dyslipidemia, Dose-response relationship, Restricted cubic spline

中图分类号: 

  • R195.2