重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS患者中结核潜伏感染的影响因素研究

doi:10.12183/j.scjpm.2024.1124

华南预防医学 ›› 2024, Vol. 50 ›› Issue (12): 1124-1129.doi: 10.12183/j.scjpm.2024.1124

重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS患者中结核潜伏感染的影响因素研究

王慧¹, 卜春红¹, 陆兴², 王金富², 竺丽梅³, 刘巧³

1.扬州市疾病预防控制中心,江苏扬州 225000;
2.扬州市第三人民医院;
3.江苏省疾病预防控制中心

收稿日期:2024-04-10 出版日期:2024-12-20 发布日期:2025-01-06
通讯作者: 卜春红,E-mail：269725276@qq.com
作者简介:王慧（1990—）,女,硕士研究生,主管医师,主要从事结核病防制工作
基金资助:
扬州市科技计划软课题研究项目（No. YZ2023305）; 江苏省卫生健康委科研项目（ZDA2020022）; 国家自然科学基金青年科学基金项目（82003516）

Influencing factors of latent tuberculosis infection among persons living with HIV/AIDS test by recombinant mycobacterium tuberculosis fusion protein

WANG Hui¹, BU Chunhong¹, LU Xing², WANG Jinfu², ZHU Limei³, LIU Qiao³

1. Yangzhou Center for Disease Control and Prevention, Yangzhou, Jiangsu 22500, China;
2. The Third People's Hospital of Yangzhou;
3. Jiangsu Provincial Center for Disease Control and Prevention

Received:2024-04-10 Online:2024-12-20 Published:2025-01-06

摘要/Abstract

摘要： 目的研究重组结核杆菌融合蛋白皮肤试验（EC-ST）筛查人免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者中结核分枝杆菌潜伏感染（LTBI）的阳性率及影响因素,为HIV/AIDS患者的结核病防治提供依据。方法选取2023年4月1日至2023年6月30日期间,需随访检测CD4+T淋巴细胞计数且符合条件的549例HIV/AIDS患者为研究对象,对其进行EC-ST检测,根据筛查结果将患者分为LTBI组和非LTBI组,探讨影响EC-ST诊断LTBI阳性率的因素。利用R语言建立限制性立方样条,分析CD4+T淋巴细胞水平与LTBI风险之间的关系。结果 CD4+T淋巴细胞水平（OR=1.002）是EC-ST筛查HIV/AIDS患者LTBI阳性率的影响因素,且与LTBI风险之间呈线性关系（非线性检验χ²=0.140,P>0.05）。结论 EC-ST在HIV/AIDS患者中筛查LTBI阳性率受CD4+T淋巴细胞水平影响。需加强HIV/AIDS患者中LTBI者健康教育与预防性治疗,重点关注对CD4+T淋巴细胞水平较低,提示有重度免疫缺陷的HIV/AIDS患者,定期对其进行LTBI筛查及健康监测。

关键词: 人免疫缺陷病毒, 获得性免疫缺陷综合征, 重组结核杆菌融合蛋白, 结核潜伏感染, 限制性立方条

Abstract: Objective To investigate the positive rate and influencing factors of recombinant mycobacterium tuberculosis fusion protein skin test (EC-ST) for screening latent tuberculosis infection (LTBI) in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients, to provide the basis for prevention and treatment of tuberculosis in HIV/AIDS patients. Methods From April 1, 2023 to June 30, 2023, 549 eligible HIV/AIDS patients requiring CD4+T lymphocyte count detection were selected as the study objects, and EC-ST detection was performed on them. According to the results of EC-ST, HIV/AIDS patients were divided into LTBI group and non-LTBI group to explore the factors affecting the positive rate of LTBI. R software was used to establish a restricted cubic spline model to fit the dose-response relationship between CD4+T lymphocyte levels and the risk of LTBI. Results CD4+T lymphocyte level was an influential factor in EC-ST screening for positive rate of LTBI in HIV/AIDS patients (OR=1.002), and was linearly correlated with the risk of LTBI (non-linear test χ²=0.140, P>0.05). Conclusions The positive rate of LTBI in EC-ST screening in HIV/AIDS patients is influenced by the level of CD4+T lymphocytes. It is necessary to strengthen health education and preventive treatment of LTBI among HIV/AIDS patients, focusing on LTBI screening and health monitoring of HIV/AIDS patients with low CD4+T lymphoid cell levels indicating severe immune deficiency.

Key words: Human immunodeficiency virus, Acquired immune deficiency syndrome, Recombinant mycobacterium tuberculosis fusion protein, Latent tuberculosis infection, Restrictive cubic spline

中图分类号:

R211

王慧, 卜春红, 陆兴, 王金富, 竺丽梅, 刘巧. 重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS患者中结核潜伏感染的影响因素研究[J]. 华南预防医学, 2024, 50(12): 1124-1129.

WANG Hui, BU Chunhong, LU Xing, WANG Jinfu, ZHU Limei, LIU Qiao. Influencing factors of latent tuberculosis infection among persons living with HIV/AIDS test by recombinant mycobacterium tuberculosis fusion protein[J]. South China Journal of Preventive Medicine, 2024, 50(12): 1124-1129.

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重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS患者中结核潜伏感染的影响因素研究

Influencing factors of latent tuberculosis infection among persons living with HIV/AIDS test by recombinant mycobacterium tuberculosis fusion protein

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