上海地区汉族人群成纤维生长因子1基因rs34018单核苷酸多态性与高血压性脑出血相关性

doi:10.12183/j.scjpm.2022.0027

摘要/Abstract

摘要： 目的研究上海地区汉族人群中成纤维生长因子1（FGF1）基因多态性与高血压性脑出血的相关性。方法采用随机抽样方法抽取上海市某医院神经内科2018年11月至2019年12月确诊并住院的初发高血压性脑出血患者作为脑出血组,选取同期在该医院体检中心体检的性别相同、年龄相近的健康人群作为对照组,收集2组人群性别、年龄、吸烟及喝酒情况,对2组人群进行体格检查及血压检测,采用外周静脉血用于血糖、血脂[甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、载脂蛋白A、载脂蛋白B/脂蛋白（a）]及FGF1 rs34018位点SNP检测,采用描述性分析方法对结果进行分析。结果共纳入58例高血压性脑出血患者,平均年龄（70.14±5.08）岁,男36例,女21例。对照组健康体检者58人,平均年龄（69.38±6.51）岁,男36例,女22例。2组的性别分布、年龄、血糖、血脂（甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、载脂蛋白A和载脂蛋白B）等分别比较,差异均无统计学意义（均P>0.05）。脑出血组舒张压和收缩压均高于对照组（均P<0.01）。2组的吸烟率、饮酒率、FGF1的SNP rs34018基因型频率和等位基因频率分别比较,差异均有统计学意义（P<0.05或P<0.01）。调整年龄、性别、血压、脂蛋白（a）、吸烟史、饮酒史,以基因型AA作为参照,基因型AG患高血压性脑出血的风险增加8.242倍（OR=9.242）,基因型GG患高血压性脑出血的风险增加32.284倍（OR=33.284）。结论上海地区汉族人群中FGF1基因多态性可能促进了高血压性脑出血,可能与rs34018位点的GG型与血清脂蛋白（a）增高密切相关。

关键词: 高血压, 脑出血, 成纤维生长因子1, 单核苷酸多态性, 基因型

Abstract: Objective To investigate the relationship between the polymorphism of the gene of fibroblast growth factor 1（FGF1） and hypertensive intracerebral hemorrhage among Han population in Shanghai. Methods Patients with primary hypertensive intracerebral hemorrhage diagnosed and hospitalized in the department of neurology of a hospital in Shanghai from November 2018 to December 2019 were randomly selected as the intracerebral hemorrhage group. Healthy people of the same gender and similar age who underwent physical examination in the physical examination center of the hospital in the same period were selected as the control group. The data of gender, age, smoking and drinking of the two groups were collected, physical examination and blood pressure measurement were carried out in the two groups. Peripheral venous blood was used to detect blood glucose, blood lipids [triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, apolipoprotein A, apolipoprotein B / lipoprotein （a）] and SNP at rs34018 locus of FGF1. The results were analyzed by descriptive analysis method. Results A total of 58 patients with hypertensive intracerebral hemorrhage were included, with an average age of （70.14±5.08） years, including 36 males and 21 females. In the control group, there were 58 healthy subjects, with an average age of （69.38±6.51） years, including 36 males and 22 females. There was no significant difference in gender, age, blood glucose and blood lipids （triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein, apolipoprotein A and apolipoprotein B） between the two groups （all P>0.05）. The diastolic and systolic blood pressures in intracerebral hemorrhage group were higher than those in control group （both P<0.01）. There were significant differences in smoking rate, drinking rate, genotype frequency and allele frequency of SNP at rs34018 locus of FGF1 between the two groups （P<0.05 or P<0.01）. After adjusting for age, gender, blood pressure, lipoprotein （a）, smoking history and drinking history, with genotype AA as a reference, the risk of hypertensive intracerebral hemorrhage in genotype AG increased by 8.242 times （OR=9.242）, and in genotype GG increased by 32.284 times （OR=33.284）. Conclusion Polymorphism of the gene of FGF1 in Han population in Shanghai may promote hypertensive intracerebral hemorrhage, which may be closely related to the GG type at rs34018 locus and the increase of serum lipoprotein （a）.

Key words: Hypertension, Intracerebral hemorrhage, Fibroblast growth factor 1, Single nucleotide polymorphism, Genotype

中图分类号:

R111

袁州, 岳孟孟, 赵迎春. 上海地区汉族人群成纤维生长因子1基因rs34018单核苷酸多态性与高血压性脑出血相关性[J]. 华南预防医学, 2022, 48(1): 27-31.

YUAN Zhou, YUE Meng-meng, ZHAO Ying-chun. Relationship between single nucleotide polymorphism of fibroblast growth factor 1 gene rs34018 and hypertensive intracerebral hemorrhage among Han population in Shanghai[J]. South China Journal of Preventive Medicine, 2022, 48(1): 27-31.

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