Abstract: Objective To determine effects of konjac compound on lipid metabolism and oxidative stress in obese rats and explore its mechanism of lipid metabolism and oxidative stress. Methods SD rats were used to establish an obesity model. The rats were divided into a model group and konjac compound administration groups at different doses. After 6 weeks of intervention, the indexes of blood lipid, adipokine, and antioxidant were detected. Results After 6 weeks of the experiment, the differences in body mass and fat/body ratio between the groups were statistically significant （P<0.05 or P<0.01）. The body weight and fat/body ratio of the konjac compound in the low, medium and high administration groups decreased with the increase of the dose concentration. Levels of serum triacylglycerol （TG）, total cholesterol （TC）, high-density lipoprotein cholesterol （HDL-C）, and blood glucose in the high-dose konjac compound group, and levels of serum TG and blood glucose in the middle-dose group decreased significantly （P<0.05 or P<0.01）. In the low-, medium-, and high-dose administration groups, HDL-C increased with the increase of konjac compound dosage. Statistically significant differences in leptin, adiponectin, superoxide dismutase （SOD）, malondialdehyde （MDA）, glutathione peroxidase （GSH-PX） were observed among the groups （P<0.05 or P<0.01）. With the increase of the konjac compound dose in the low-, medium-, and high-dose groups, the serum leptin and MDA levels decreased, but the levels of adiponectin, SOD, and GSH-PX increased. Conclusion The konjac compound can effectively improve the blood lipid disorder, reduce fat and weight, inhibit the oxidative stress reaction in the process of obesity, and prevent and treat obesity of obese rats.

Key words: Konjac, Obesity, Lipid metabolism, Oxidative stress, Mechanism