Abstract: Objective To investigate the association between dietary vitamin intake and carotid artery stenosis in patients with ischemic stroke. Methods Patients with ischemic stroke hospitalized in Jinling Hospital from January 2016 to December 2019 were included. Dietary vitamin intake was assessed with food questionnaire. Carotid artery stenosis was evaluated with computed tomography angiography （CTA）. Blood neutrophil count, lymphocyte count, serum homocysteine （Hcy）, C-reactive protein （CRP）, and hemoglobin A1c（HbA1c） were detected. Ordered Logistic regression analysis was used to evaluate the association between dietary vitamin intake and carotid artery stenosis. Results A total of 628 patients with ischemic stroke were enrolled, with an average age of （64.8±10.9） years, 390 （62.1%） were detected with carotid artery stenosis. Ordered Logistic regression showed that vitamin B₃ （OR=0.954, 95% CI： 0.913-0.997）, vitamin B₆ （OR=0.634, 95% CI： 0.407-0.989） and vitamin B₁₂ （OR=0.796, 95%CI： 0.663-0.956） were independent predicators of the degree of carotid artery stenosis. Conclusion Dietary vitamin intake in patients with ischemic stroke may influence the degree of carotid artery stenosis. Maintaining adequate intake of vitamin B₃, B₆ and B₁₂ may be beneficial for preventing development of atherosclerosis.

Key words: Ischemic stroke, Diet, Vitamin, Atherosclerosis