Abstract: Objective To understand the cognition, intention to use and influencing factors of HIV pre-exposure prophylaxis（PrEP） among men who have sex with men（MSM） in Kunming Province, in order to provide evidence for PrEP program. Methods Quantitative and qualitative methods were carried out to investigate MSM patients aged ≥16 years, who had anal sex with men in the last year and HIV negative. Non-probabilistic “snowball” sampling was used in the quantitative survey, which included demographic characteristics, personal sexual behavior, PrEP awareness and usage intention, etc. Qualitative adopted the method of intention sampling, including cognition of PrEP, willingness to use when not free, psychological expectations, and prevention measures of HIV, etc. Results A total of 396 valid questionnaires were collected. 63.9%（253/396）had heard of PrEP, if the drug was free, 92.4%（366/396）were willing to take PrEP. Multivariate Logistic regression analysis showed that likely to be infected with HIV over the next five years（OR=14.192）, no worry about PrEP expensive cannot afford（OR=6.023）, had heard of PrEP（OR=3.291）, and non-marital cohabitation （OR=6.603） were independent protect factors to use PrEP. The against for PrEP by gay friend （OR=0.015） was independent obstructive factors. The qualitative showed that 8 out of 11 MSM had heard of PrEP, but 5 person did not know what is PrEP. When it was not free 8 out of 11 said would not use drug because of the high prices, side effects and efficacy was not 100%. They were willing to pay 945.5~1 000.0 yuan a month if needed in the future. Conclusion The willingness of HIV PrEP use among MSM in Kunming is high, but lack of cognition. Personal risk awareness, attitude of gay friend, have heard of PrEP and the price may be the influening factors of PrEP to use.

Key words: Men who have sex with men, HIV, Pre-exposure prophylaxis, Intention to use, Influencing factor