Abstract: Objective To analyze the changing trend of diabetes mortality and untimely death probability in Guangdong Province, so as to provide reference for future research and prevention of diabetes mortality. Methods Data were collected from Guangdong Death Cause Monitoring System from 2005 to 2015, and the mortality, standardized mortality, untimely death probability, and annual percent change （APC） of diabetes were calculated. Chi-square test was used for the comparison of rates, Student's t test was used for the APC. Results From 2005 to 2015, the proportion of diabetes mortality in the total mortality in Guangdong Province decreased from 1.40% to 1.30% （APC=-1.09%, P<0.01）; The mortality rate of diabetes decreased from 7.13/100 000 to 6.26/100 000 （APC=-1.69%, P<0.01）; The standardized mortality rate of diabetes decreased from 10.37/100 000 to 7.79/100 000 （APC=- 3.15%, P<0.01）; The untimely death probability of diabetes decreased from 0.47% to 0.32% （APC=-4.11%, P<0.01）; The standardized mortality and untimely death probability of diabetes in 21 cities of Guangdong Province decreased year by year （all P<0.01）. Conclusion Although the overall mortality of diabetes in Guangdong Province is declining, it is still the main disease endangering the health of residents. There is a need for further sustained implementation of universal interventions.

Key words: Diabetes, Mortality, Untimely death probability, Annual percent change