Abstract: Objective To explore the incidence and influencing factors of postherpetic neuralgia （PHN） in Xiangyang City. Methods Patients with herpes zoster who were hospitalized in three tertiary hospitals in Xiangyang City from January to December 2021 were selected as the subjects. General data of patients was collected through a questionnaire survey. The occurrence of PHN was analyzed by descriptive analysis method, and the influencing factors of PHN in patients with herpes zoster were analyzed by univariate and multivariate analysis methods. Results A total of 2 175 patients with herpes zoster were included in this study, of which 441 patients developed PHN, with an incidence rate of 20.28%. Among them, there were 80 patients with mild pain, accounting for 18.14%; 288 patients with moderate pain, accounting for 65.31%; 73 patients with severe pain, accounting for 16.55%. Multivariate analysis showed that ageing （OR=1.040）, trigeminal nerve involvement （OR=2.078）, abnormal CD4+/CD8+ ratio （OR=2.680）, skin lesion area≥5% （OR=1.735）, secondary bacterial infection in skin lesions （OR=1.987）, time from onset to first diagnosis ≥5 days （OR=2.124）, diabetes （OR=1.520）, anxiety （OR=3.819）, and sleep disorders （OR=1.528） were risk factors for PHN in patients with herpes zoster. Conclusions The incidence of PHN in patients with herpes zoster in Xiangyang City is relatively high. Age, trigeminal nerve involvement, abnormal CD4+/CD8+ ratio, and skin lesion area ≥5% are the factors affecting the occurrence of PHN. Patients with herpes zoster should seek medical attention in a timely manner, adopt standardized treatment, and prevent the occurrence of PHN.

Key words: Herpes zoster, Postherpetic neuralgia, Influencing factor