Abstract: Objective To investigate the physiological subhealth status of medical personnel and its effect relationship with the various influencing factors, and put forward the protective strategy against the physiological subhealth status of medical personnel. Method A questionnaire was used to investigate the physiological subhealth status of 672 medical personnel in 39 medical and health institutions in Panyu District, Guangzhou from December 2022 to January 2023, and the effect relationship between the physiological subhealth status of medical personnel and various influencing factors was analyzed by path analysis. Results The average score of physiological subhealth assessment for medical personnel was （28.47 ± 7.74） out of 44. The top three factors that positively affected the total effect of the physiological subhealth status of medical personnel were the degree to which they perceive their work to positively affect the lives of others, their sense of work achievement, and regular dining, with standardized total effects of 0.358, 0.296, and 0.263, respectively. The top three factors for the negative total effect were stress perception, weekly overtime days, and average working time per day, with standardized total effects of -0.627, -0.144, and -0.097, respectively. Conclusions The occurrence of physiological subhealth among medical personnel is caused by multiple factors. It is recommended that medical and health institutions reduce the incidence of physiological subhealth among medical personnel by reducing work pressure, cultivating positive work attitudes among employees, arranging workload reasonably, and advocating healthy lifestyles.

Key words: Subhealth status, Path analysis, Medical personnel, Work stress, Influencing factor