Abstract: Objective To analyze the knowledge, attitude, and practice of secondary prevention in patients with ischemic stroke in Shangqiu City, as well as their influencing factors. Methods Convenient sampling method was used to select patients with stable ischemic stroke who were diagnosed and treated in two hospitals in Shangqiu City from June 2022 to June 2023 for this study. The knowledge, attitude, and practice of secondary prevention were investigated, and the influencing factors were analyzed. Results A total of 1 530 patients with stable ischemic stroke were investigated, of which 1 483 were effectively investigated, aged 18-76 years old, with a higher proportion of ≥61 years old. The sex ratio of male to female was 1.328∶1. The total average scores of secondary prevention knowledge, attitude, and practice were （30.03±5.88）, （40.63±7.62）, and （38.73±8.22）, respectively. Multiple linear regression analysis showed that age （β′= 0.184, 0.115, 0.187）, combined with underlying diseases （β′= 0.253, 0.266, 0.221）, family history of ischemic stroke （β′= 0.195, 0.071, 0.204）, receiving publicity/lectures on ischemic stroke （β′= 0.256, 0.189, 0.217）, social support （β′= 0.319, 0.613, 0.375）were the common influencing factors on the scores of prevention and control knowledge, attitude, and practice （all P <0.05）. Educational level （β′= 0.263, 0.394）, marital status （β′= 0.152, 0.148）, and resident manner （β′= 0.176, 0.261）were the influencing factors of prevention and control knowledge and practice （all P<0.05）. Disease duration （β′= 0.284）was the influencing factor of prevention and control attitude （P<0.05）. According to Pearson correlation analysis, there was a significant positive correlation （all P<0.05）between knowledge and attitude （r=0.449）, knowledge and practice （r=0.621）, and attitude and practice （r=0.635）. Conclusions The levels of knowledge, attitude, and practice of secondary prevention in patients with stable ischemic stroke in Shangqiu City are generally low. Active measures can be taken to improve the levels of knowledge, attitude, and practice of secondary prevention in patients through age, complicated underlying diseases, family history of ischemic stroke, receiving publicity/lectures on ischemic stroke, and social support.

Key words: Ischemic stroke, Secondary prevention, Knowledge, attitude, and practice, Influencing factor