Abstract: Objective To investigate the adherence to antiretroviral therapy （ART） and its influencing factors among HIV/AIDS patients. Methods A questionnaire survey was conducted among HIV/AIDS patients undergoing ART in Huangpu District, Guangzhou. The survey content included self-made questionnaire, multidimensional scale of perceived social support, and visual analogue scale. Univariate and multivariate logistic regressions were used to determine factors associated with ART adherence. Results A total of 205 valid questionnaires were collected. The average age of the respondents was （35.79 ± 10.66） years. Of all the respondents, 183 （89.3%） were males, 102 （49.8%） unmarried, 93 （45.4%） had occupations of workers or migrant workers, 81 （39.5 %） were college graduates or above, and 121 （59.0%） were infected through homosexual transmission. The adherence to ART was good at 75.6%, of which 21.5% had an on-time medication rate of 90% -94%. The HIV/AIDS patients aged 25-39 years （OR=0.28）, with occupations of worker/migrant worker, others （unemployed, student, etc.） （OR=0.13, 0.13）, the latest CD4 count ≥350 / μL and 500/ μL（OR=0.34, 0.13）, and intermediate social support status （OR=0.24） had poor adherence to ART. Those who persisted in taking medicines regime to prolong life （OR=5.15） and were satisfied with the service of follow-up doctors （OR=3.90） had better adherence to ART. Conclusion The adherence to ART was moderate for the HIV/AIDS patients in Huangpu District and influenced by many factors. Active intervention measures should be taken to improve the adherence to ART.

Key words: HIV/AIDS, ART, Adherence, Influencing factor