Abstract: Objective To investigate and analyze a family clustering of COVID-19 in ZH City, Guangdong Province, with a view to providing more evidence for the scientific prevention and control of COVID-19. Methods Field epidemiological method was used to survey the cases and related close contacts. Real time-PCR technique was used to detect SARS-CoV-2 nucleic acid in throat swab samples collected from the respondents. Results After the onset of the first case on January 28, 6 confirmed cases had occurred in this family, and the epidemic had affected 4 small families with a total of 7 cases. The main symptoms were respiratory symptoms, including 1 critical case,1 severe case, and 5 common cases. The median age of 7 cases was 63 years （36-67 years）; 3 were males and 4 were females. The median exposure-onset interval was 8 d （7-14 d）. Conclusion The early transmission of COVID-19 is prone to family aggregation, and the centralized isolation of single people and single room in the early stage of the epidemic can effectively cut off the transmission route within the family.

Key words: COVID-19, Family clustering, Epidemiological